CAS OpenIR
Supramolecular assembly of protein-based nanoparticles based on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) for cancer therapy
Li, Hong1; Zhao, Jie2; Wang, Anhe3; Li, Qi3; Cui, Wei2
2020-04-05
Source PublicationCOLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
Volume590Pages:6
AbstractMolecular self-assembly of functional proteins has garnered intense interest for the development of nanomaterials. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), as one of the most promising agents for cancer therapy, could selectively induce the apoptotic cell death in tumor cells while not on normal cells. In this study, protein-based nanoparticles were constructed with TRAIL and a dipeptide, diphenylalanine (FF), through molecular self-assembly. TRAIL-FF nanoparticles with sizes ranging from 60 nm to 500 nm could be prepared by controlling the concentration and the ratio of the two components. These nanoparticles could locate around the cytomembrane of MCF-7 cells due to the specific interaction between TRAIL and death receptors, thus transduce apoptotic signal. Therefore, the TRAIL-FF nanoparticles showed distinct killing effect on the cancer cells, such as MCF-7 and H460 cells, and the IC50 of the nanoparticles on H460 cells was about 260 ng/mL. The approach presented herein may be applicable to the fabrication of an extended range of protein-based functional biomaterials.
KeywordTRAIL Diphenylalanine Self-assembly Cancer therapy
DOI10.1016/j.colsurfa.2020.124486
Language英语
WOS KeywordDOPAMINE ; PEPTIDE ; NANOSTRUCTURES ; MICROCAPSULES ; CONSTRUCTION ; FABRICATION
Funding ProjectNational Natural Science Foundation of China[21872150] ; National Natural Science Foundation of China[21433010] ; National Natural Science Foundation of China[21703169] ; National Natural Science Foundation of China[2191101022] ; Natural Science Foundation of Shaanxi Province of China[2018JQ2047] ; Young Talent fund of University Association for Science and Technology in Shaanxi Province of China[20190605]
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
Funding OrganizationNational Natural Science Foundation of China ; Natural Science Foundation of Shaanxi Province of China ; Young Talent fund of University Association for Science and Technology in Shaanxi Province of China
WOS IDWOS:000513862500012
PublisherELSEVIER
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/39564
Collection中国科学院过程工程研究所
Corresponding AuthorCui, Wei
Affiliation1.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 710065, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Li, Hong,Zhao, Jie,Wang, Anhe,et al. Supramolecular assembly of protein-based nanoparticles based on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) for cancer therapy[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2020,590:6.
APA Li, Hong,Zhao, Jie,Wang, Anhe,Li, Qi,&Cui, Wei.(2020).Supramolecular assembly of protein-based nanoparticles based on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) for cancer therapy.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,590,6.
MLA Li, Hong,et al."Supramolecular assembly of protein-based nanoparticles based on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) for cancer therapy".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 590(2020):6.
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