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Sheathless Inertial Focusing Chip Combining a Spiral Channel with Periodic Expansion Structures for Efficient and Stable Particle Sorting
Gou, Yixing1,2; Zhang, Shuai3; Sun, Changku1; Wang, Peng1; You, Zheng2; Yalikun, Yaxiaer4,5; Tanaka, Yo4; Ren, Dahai2
2020-01-21
Source PublicationANALYTICAL CHEMISTRY
ISSN0003-2700
Volume92Issue:2Pages:1833-1841
AbstractEfficient and reliable manipulation of biological particles is crucial in medical diagnosis and chemical synthesis. Inertial microfluidic devices utilizing passive hydrodynamic forces in the secondary flow have drawn considerable attention for their high throughputs, low costs, and harmless particle manipulation. However, as the dominant mechanism, the inertial lift force is difficult to quantitatively analyze because of the uncertainties of its magnitude and direction. The equilibrium position of particles varies along the migration process, thus inducing the instabilities of particle separation. Herein, we present a designable inertial microfluidic chip combining a spiral channel with periodic expansion structures for the sheathless separation of particles with different sizes. The stable vortex-induced lift force arising from the periodic expansion and the Dean drag force significantly enhanced the focusing process and determined the final equilibrium position. The experimental results showed that over 99% of target particles could be isolated with the high target sample purity of 86.12%. In the biological experiment, 93.5% of the MCF-7, 89.5% of the Hela, and 88.6% of the A549 cells were steadily recovered with excellent viabilities to verify the potential of the device in dealing with biological particles over a broad range of throughputs. The device presented in this study can further serve as a lab-on-chip platform for liquid biopsy and diagnostic analysis.
DOI10.1021/acs.analchem.9b03692
Language英语
WOS KeywordCIRCULATING TUMOR-CELLS ; LABEL-FREE ISOLATION ; ULTRA-FAST ; SEPARATION ; BLOOD ; MICROFLUIDICS ; SYSTEM ; CANCER ; FLOWS ; LIFT
Funding ProjectNational Natural Science Foundation of China[61071002] ; National Program for Significant Scientific Instruments Development of China[2011YQ030134] ; Funds of State Key Laboratory of China ; Funds of Beijing Laboratory of Biomedical Detection Technology and Instrument ; Beijing Innovation Center for Future Chips
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
Funding OrganizationNational Natural Science Foundation of China ; National Program for Significant Scientific Instruments Development of China ; Funds of State Key Laboratory of China ; Funds of Beijing Laboratory of Biomedical Detection Technology and Instrument ; Beijing Innovation Center for Future Chips
WOS IDWOS:000509420400027
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/39591
Collection中国科学院过程工程研究所
Corresponding AuthorRen, Dahai
Affiliation1.Tianjin Univ, State Key Lab Precis Measurement Technol & Instru, Tianjin 300072, Peoples R China
2.Tsinghua Univ, Dept Precis Instrument, State Key Lab Precis Measurement Technol & Instru, Beijing 100084, Peoples R China
3.Chinese Acad Sci, State Key Lab Multiphase Complex Syst, Inst Proc Engn, Beijing 100190, Peoples R China
4.RIKEN, Ctr Biosyst Dynam Res BDR, 1-3 Yamadaoka, Suita, Osaka 5650871, Japan
5.Nara Inst Sci & Technol, Div Mat Sci, 8916-5 Takayama Cho, Ikoma, Nara 6300192, Japan
Recommended Citation
GB/T 7714
Gou, Yixing,Zhang, Shuai,Sun, Changku,et al. Sheathless Inertial Focusing Chip Combining a Spiral Channel with Periodic Expansion Structures for Efficient and Stable Particle Sorting[J]. ANALYTICAL CHEMISTRY,2020,92(2):1833-1841.
APA Gou, Yixing.,Zhang, Shuai.,Sun, Changku.,Wang, Peng.,You, Zheng.,...&Ren, Dahai.(2020).Sheathless Inertial Focusing Chip Combining a Spiral Channel with Periodic Expansion Structures for Efficient and Stable Particle Sorting.ANALYTICAL CHEMISTRY,92(2),1833-1841.
MLA Gou, Yixing,et al."Sheathless Inertial Focusing Chip Combining a Spiral Channel with Periodic Expansion Structures for Efficient and Stable Particle Sorting".ANALYTICAL CHEMISTRY 92.2(2020):1833-1841.
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