Knowledge Management System Of Institute of process engineering,CAS
| Injectable self-assembled bola-dipeptide hydrogels for sustained photodynamic prodrug delivery and enhanced tumor therapy | |
| Zou, Qianli1; Chang, Rui1,2; Xing, Ruirui1; Yuan, Chengqian1; Yan, Xuehai1,2,3 | |
| 2020-03-10 | |
| Source Publication | JOURNAL OF CONTROLLED RELEASE
 |
| ISSN | 0168-3659 |
| Volume | 319Pages:344-351 |
| Abstract | Supramolecular peptide materials have attracted increasing attention due to their natural biological origin and versatile applications. However, it is often challenging to control and modulate the self-assembly of peptides (especially short peptides) for constructing hydrogels with tunable mechanical properties and adaptive injectability toward biomedical applications. Here, we report a supramolecular strategy for forming robust and injectable hydrogels based on the self-assembly of a rationally designed bola-dipeptide. The self-assembled hydrogels exhibit versatile functionalities, including flow under shear stress, good recovery properties, and easy encapsulation of hydrophilic prodrugs. The prodrug-loaded hydrogels show sustained release profiles, inhibited nontargeted leakage, and enhanced localized prodrug conversion, leading to highly efficient photodynamic tumor ablation. Hence, the supramolecular strategy is promising for the rational construction of injectable hydrogels toward targeted and sustained prodrug conversion and tumor therapy. |
| Keyword | Bola-dipeptide 5-aminolevulinic acid Hydrogel Self-assembly Photodynamic therapy |
| DOI | 10.1016/j.jconrel.2020.01.002 |
| Language | 英语 |
| WOS Keyword | 5-AMINOLEVULINIC ACID ; BETA-SHEET |
| Funding Project | National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21802143] ; National Natural Science Foundation of China[21977095] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; Youth Innovation Promotion Association CAS[2019051] |
| WOS Research Area | Chemistry ; Pharmacology & Pharmacy |
| WOS Subject | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| Funding Organization | National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; Youth Innovation Promotion Association CAS |
| WOS ID | WOS:000515538300026 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/39643 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Yan, Xuehai |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China |
| First Author Affilication | Center of lonic Liquids and Green Engineering |
| Corresponding Author Affilication | Center of lonic Liquids and Green Engineering |
| Recommended Citation GB/T 7714 | Zou, Qianli,Chang, Rui,Xing, Ruirui,et al. Injectable self-assembled bola-dipeptide hydrogels for sustained photodynamic prodrug delivery and enhanced tumor therapy[J]. JOURNAL OF CONTROLLED RELEASE,2020,319:344-351. |
| APA | Zou, Qianli,Chang, Rui,Xing, Ruirui,Yuan, Chengqian,&Yan, Xuehai.(2020).Injectable self-assembled bola-dipeptide hydrogels for sustained photodynamic prodrug delivery and enhanced tumor therapy.JOURNAL OF CONTROLLED RELEASE,319,344-351. |
| MLA | Zou, Qianli,et al."Injectable self-assembled bola-dipeptide hydrogels for sustained photodynamic prodrug delivery and enhanced tumor therapy".JOURNAL OF CONTROLLED RELEASE 319(2020):344-351. |
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