CAS OpenIR
Injectable self-assembled bola-dipeptide hydrogels for sustained photodynamic prodrug delivery and enhanced tumor therapy
Zou, Qianli1; Chang, Rui1,2; Xing, Ruirui1; Yuan, Chengqian1; Yan, Xuehai1,2,3
2020-03-10
Source PublicationJOURNAL OF CONTROLLED RELEASE
ISSN0168-3659
Volume319Pages:344-351
AbstractSupramolecular peptide materials have attracted increasing attention due to their natural biological origin and versatile applications. However, it is often challenging to control and modulate the self-assembly of peptides (especially short peptides) for constructing hydrogels with tunable mechanical properties and adaptive injectability toward biomedical applications. Here, we report a supramolecular strategy for forming robust and injectable hydrogels based on the self-assembly of a rationally designed bola-dipeptide. The self-assembled hydrogels exhibit versatile functionalities, including flow under shear stress, good recovery properties, and easy encapsulation of hydrophilic prodrugs. The prodrug-loaded hydrogels show sustained release profiles, inhibited nontargeted leakage, and enhanced localized prodrug conversion, leading to highly efficient photodynamic tumor ablation. Hence, the supramolecular strategy is promising for the rational construction of injectable hydrogels toward targeted and sustained prodrug conversion and tumor therapy.
KeywordBola-dipeptide 5-aminolevulinic acid Hydrogel Self-assembly Photodynamic therapy
DOI10.1016/j.jconrel.2020.01.002
Language英语
WOS Keyword5-AMINOLEVULINIC ACID ; BETA-SHEET
Funding ProjectNational Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21802143] ; National Natural Science Foundation of China[21977095] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; Youth Innovation Promotion Association CAS[2019051]
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; Youth Innovation Promotion Association CAS
WOS IDWOS:000515538300026
PublisherELSEVIER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/39643
Collection中国科学院过程工程研究所
Corresponding AuthorYan, Xuehai
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zou, Qianli,Chang, Rui,Xing, Ruirui,et al. Injectable self-assembled bola-dipeptide hydrogels for sustained photodynamic prodrug delivery and enhanced tumor therapy[J]. JOURNAL OF CONTROLLED RELEASE,2020,319:344-351.
APA Zou, Qianli,Chang, Rui,Xing, Ruirui,Yuan, Chengqian,&Yan, Xuehai.(2020).Injectable self-assembled bola-dipeptide hydrogels for sustained photodynamic prodrug delivery and enhanced tumor therapy.JOURNAL OF CONTROLLED RELEASE,319,344-351.
MLA Zou, Qianli,et al."Injectable self-assembled bola-dipeptide hydrogels for sustained photodynamic prodrug delivery and enhanced tumor therapy".JOURNAL OF CONTROLLED RELEASE 319(2020):344-351.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zou, Qianli]'s Articles
[Chang, Rui]'s Articles
[Xing, Ruirui]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zou, Qianli]'s Articles
[Chang, Rui]'s Articles
[Xing, Ruirui]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zou, Qianli]'s Articles
[Chang, Rui]'s Articles
[Xing, Ruirui]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.