CAS OpenIR
Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment via nanotechnology
Yang, Jun1; Shi, Zhuyan1,2; Liu, Ruiyuan1,2; Wu, Yanyue1,2; Zhang, Xin1
2020
Source PublicationTHERANOSTICS
ISSN1838-7640
Volume10Issue:7Pages:3223-3239
AbstractGlioblastoma multiforme (GBM) is a highly aggressive and devastating brain tumor characterized by poor prognosis and high rates of recurrence. Numerous therapeutic strategies and delivery systems are developed to prolong the survival time. They exhibit enhanced therapeutic effects in animal models, whereas few of them is applied in clinical trials. Taking into account the drug-resistance and high recurrence of GBM, combined-therapeutic strategies are exploited to maximize therapeutic efficacy. The combined therapies demonstrate superior results than those of single therapies against GBM. The co-therapeutic agents, the timing of therapeutic strategies and the delivery systems greatly affect the overall outcomes. Herein, the current advances in combined therapies for glioblastoma via systemic administration are exhibited in this review. And we will discuss the pros and cons of these combined-therapeutic strategies via nanotechnology, and provide the guidance for developing rational delivery systems to optimize treatments against GBM and other malignancies in central nervous system.
Keywordglioblastoma combined therapy nanotechnology drug delivery
DOI10.7150/thno.40298
Language英语
WOS KeywordNEAR-INFRARED PHOTOIMMUNOTHERAPY ; UP-CONVERSION NANOPARTICLES ; BLOOD-BRAIN-BARRIER ; CO-DELIVERY SYSTEM ; GENE-THERAPY ; RECURRENT GLIOBLASTOMA ; PHOTODYNAMIC THERAPY ; STEM-CELLS ; PHASE-II ; PHOTOTHERMAL THERAPY
Funding ProjectBeijing Natural Science Foundation[2192057] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[51573188] ; National Natural Science Foundation of China[21875254] ; National High Technology Research and Development Program[2016YFA0200303]
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
Funding OrganizationBeijing Natural Science Foundation ; National Natural Science Foundation of China ; National High Technology Research and Development Program
WOS IDWOS:000514452800023
PublisherIVYSPRING INT PUBL
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/39821
Collection中国科学院过程工程研究所
Corresponding AuthorZhang, Xin
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yang, Jun,Shi, Zhuyan,Liu, Ruiyuan,et al. Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment via nanotechnology[J]. THERANOSTICS,2020,10(7):3223-3239.
APA Yang, Jun,Shi, Zhuyan,Liu, Ruiyuan,Wu, Yanyue,&Zhang, Xin.(2020).Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment via nanotechnology.THERANOSTICS,10(7),3223-3239.
MLA Yang, Jun,et al."Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment via nanotechnology".THERANOSTICS 10.7(2020):3223-3239.
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