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| Graphene oxide-based nanocomposite enabled highly efficient targeted synergistic therapy for colorectal cancer | |
| Qiu, Zhichao1,2,3; Hu, Jing2; Li, Ziwei3; Yang, Xiaoxue3; Hu, Jun3; You, Qingjun1; Bai, Shuo4; Mao, Yong1; Hua, Dong1; Yin, Jian3 | |
| 2020-05-20 | |
| Source Publication | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
 |
| ISSN | 0927-7757 |
| Volume | 593Pages:8 |
| Abstract | Integrating different therapies into a single nanoplatform has shown great potential for synergistic anti-tumor therapy. In this work, we fabricated the graphene oxide (GO)-based nanosheets loaded with chemotherapeutic drug 5-fluorouracil (5-FU) and modified with GE11, which is an efficient ligand for epidermal growth factor receptor (EGFR). The nanocomposite system 5-FU/GO-PEG-GE11 was found to transfer 5-FU into EGFR-overexpressing HCT-116 cells effectively. The oxidation of glutathione in the tumor cells was found to be accelerated and then destroy the intracellular redox balance after irradiation. The 5-FU/GO-PEG-GE11 nanocomposites exhibited an enhanced synergistic anti-tumor efficacy both in vitro and in vivo. Tumor inhibition rate was 90 % in subcutaneous colorectal cancer (CRC) bearing mouse model. The GO-based nanocomposites serve as a versatile platform integrated of PTT and chemotherapy with EGFR-targeting ability, which hold great promise for CRC treatment. |
| Keyword | Graphene oxide GE11 Drug delivery GSH Chemo-photothermal therapy |
| DOI | 10.1016/j.colsurfa.2020.124585 |
| Language | 英语 |
| WOS Keyword | HYBRID HYDROGELS ; DRUG-DELIVERY ; COLON-CANCER ; 5-FLUOROURACIL ; CHEMOTHERAPY ; EGFR |
| Funding Project | National Natural Science Foundation of China[31700706] ; National Natural Science Foundation of China[21877052] ; Natural Science Foundation of Jiangsu Province[BK20180030] ; Natural Science Foundation of Jiangsu Province[BK20171150] ; National Key R&D Program of China[2018YFA0901700] ; National First-class Discipline Program of Light Industry Technology and Engineering[LITE2018-14] ; Fundamental Research Funds for the Central Universities[JUSRP51712B] ; Max Planck Society International Partner Group Program ; "Six Talents Summit" funded project of Jiangsu Province[WSN-188] |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Physical |
| Funding Organization | National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; National Key R&D Program of China ; National First-class Discipline Program of Light Industry Technology and Engineering ; Fundamental Research Funds for the Central Universities ; Max Planck Society International Partner Group Program ; "Six Talents Summit" funded project of Jiangsu Province |
| WOS ID | WOS:000521957200017 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/39855 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Hu, Jing; Mao, Yong; Hua, Dong |
| Affiliation | 1.Jiangnan Univ, Dept Oncol, Affiliated Hosp, Wuxi 214062, Jiangsu, Peoples R China 2.Jiangnan Univ, Wuxi Sch Med, Wuxi 214122, Jiangsu, Peoples R China 3.Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Qiu, Zhichao,Hu, Jing,Li, Ziwei,et al. Graphene oxide-based nanocomposite enabled highly efficient targeted synergistic therapy for colorectal cancer[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2020,593:8. |
| APA | Qiu, Zhichao.,Hu, Jing.,Li, Ziwei.,Yang, Xiaoxue.,Hu, Jun.,...&Yin, Jian.(2020).Graphene oxide-based nanocomposite enabled highly efficient targeted synergistic therapy for colorectal cancer.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,593,8. |
| MLA | Qiu, Zhichao,et al."Graphene oxide-based nanocomposite enabled highly efficient targeted synergistic therapy for colorectal cancer".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 593(2020):8. |
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