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| Gd-metallofullerenol drug delivery system mediated macrophage polarization enhances the efficiency of chemotherapy | |
| Tang, Jinglong1,2; Zhang, Ruirui1,3; Guo, Mengyu1; Zhou, Huige1; Zhao, Yuliang1; Liu, Ying1; Wu, Yan1; Chen, Chunying1 | |
| 2020-04-10 | |
| Source Publication | JOURNAL OF CONTROLLED RELEASE
 |
| ISSN | 0168-3659 |
| Volume | 320Pages:293-303 |
| Abstract | Treatment of solid tumors by chemotherapy is usually failed in clinical because of its low effectiveness and side effects. Stimulation of immune system in vivo to fight cancer has been proved to be a pleasant complementary to systemic chemotherapy. Herein, we have developed a combination cancer therapy strategy by using polymer nanoparticles to deliver Gd-metallofullerenol and doxorubicin simultaneously. The Gd-metallofullerenol provoked the Th1 immune response by regulating the M1 macrophage polarization and the doxorubicin realized direct tumor cells killing by its cytotoxic effect. Also, the Gd-metallofullerenol as part of component in delivery system enhances the encapsulation efficiency of doxorubicin in polymer cargo for potential passive tumor target. The biocompatible and reliable method by combining nanoparticle-induced immune modulation and chemotherapy triggers systemic antitumor immune responses for the synergistic inhibition of tumor growth in vivo. The integration of Gd-metallofullerenol and doxorubicin with potentially complementary functions in one nanoplatform may provide new opportunities to improve cancer treatments. |
| Keyword | Gd-metallofullerenol Doxorubicin delivery system Macrophage polarization Combination cancer therapy |
| DOI | 10.1016/j.jconrel.2020.01.053 |
| Language | 英语 |
| WOS Keyword | NANOPARTICLES ; IMMUNOTHERAPY ; DOXORUBICIN ; THERAPY |
| Funding Project | Ministry of Science and Technology of China (National Basic Research Program)[2016YFA0201600] ; Ministry of Science and Technology of China (National Basic Research Program)[2016YFE0133100] ; National Science Foundation of China[81872651] ; National Science Foundation of China[31571027] ; National Science Foundation of China[21705151] ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China[11621505] ; CAS Key Research Program for Frontier Sciences[QYZDJ-SS-SLH022] ; CAS Interdisciplinary Innovation Team |
| WOS Research Area | Chemistry ; Pharmacology & Pharmacy |
| WOS Subject | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| Funding Organization | Ministry of Science and Technology of China (National Basic Research Program) ; National Science Foundation of China ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China ; CAS Key Research Program for Frontier Sciences ; CAS Interdisciplinary Innovation Team |
| WOS ID | WOS:000522794800024 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/39900 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Wu, Yan; Chen, Chunying |
| Affiliation | 1.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Qingdao Univ, Sch Publ Hlth, Qingdao 226021, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Beijing Key Lab Ion Liquids Clean Proc, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Tang, Jinglong,Zhang, Ruirui,Guo, Mengyu,et al. Gd-metallofullerenol drug delivery system mediated macrophage polarization enhances the efficiency of chemotherapy[J]. JOURNAL OF CONTROLLED RELEASE,2020,320:293-303. |
| APA | Tang, Jinglong.,Zhang, Ruirui.,Guo, Mengyu.,Zhou, Huige.,Zhao, Yuliang.,...&Chen, Chunying.(2020).Gd-metallofullerenol drug delivery system mediated macrophage polarization enhances the efficiency of chemotherapy.JOURNAL OF CONTROLLED RELEASE,320,293-303. |
| MLA | Tang, Jinglong,et al."Gd-metallofullerenol drug delivery system mediated macrophage polarization enhances the efficiency of chemotherapy".JOURNAL OF CONTROLLED RELEASE 320(2020):293-303. |
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