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Self-Assembling Proteins for Design of Anticancer Nanodrugs
Zou, Qianli1; Chang, Rui1; Yan, Xuehai1,2
2020-03-31
Source PublicationCHEMISTRY-AN ASIAN JOURNAL
ISSN1861-4728
Pages16
AbstractInspired by the diverse protein-based structures and materials in organisms, proteins have been expected as promising biological components for constructing nanomaterials toward various applications. In numerous studies protein-based nanomaterials have been constructed with the merits of abundant bioactivity and good biocompatibility. However, self-assembly of proteins as a dominant approach in constructing anticancer nanodrugs has not been reviewed. Here, we provide a comprehensive account of the role of protein self-assembly in fabrication, regulation, and application of anticancer nanodrugs. The supramolecular strategies, building blocks, and molecular interactions of protein self-assembly as well as the properties, functions, and applications of the resulting nanodrugs are discussed. The applications in chemotherapy, radiotherapy, photodynamic therapy, photothermal therapy, gene therapy, and combination therapy are included. Especially, manipulation of molecular interactions for realizing cancer-specific response and cancer theranostics are emphasized. By expounding the impact of molecular interactions on therapeutic activity, rational design of highly efficient protein-based nanodrugs for precision anticancer therapy can be envisioned. Also, the challenges and perspectives in constructing nanodrugs based on protein self-assembly are presented to advance clinical translation of protein-based nanodrugs and next-generation nanomedicine.
KeywordProtein Self-assembly Intermolecular interactions Nanodrugs Cancer therapy
DOI10.1002/asia.202000135
Language英语
WOS KeywordHUMAN SERUM-ALBUMIN ; DRUG-DELIVERY ; PHOTODYNAMIC THERAPY ; GOLD NANOPARTICLE ; BOUND PACLITAXEL ; CANCER-THERAPY ; THERANOSTICS ; TRANSFERRIN ; LIGAND ; HSA
Funding ProjectNational Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21977095] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; CAS President's International Fellowship Initiative[2018VEA0005] ; Youth Innovation Promotion Association CAS[2019051]
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS) ; CAS President's International Fellowship Initiative ; Youth Innovation Promotion Association CAS
WOS IDWOS:000522513000001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/39906
Collection中国科学院过程工程研究所
Corresponding AuthorYan, Xuehai
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zou, Qianli,Chang, Rui,Yan, Xuehai. Self-Assembling Proteins for Design of Anticancer Nanodrugs[J]. CHEMISTRY-AN ASIAN JOURNAL,2020:16.
APA Zou, Qianli,Chang, Rui,&Yan, Xuehai.(2020).Self-Assembling Proteins for Design of Anticancer Nanodrugs.CHEMISTRY-AN ASIAN JOURNAL,16.
MLA Zou, Qianli,et al."Self-Assembling Proteins for Design of Anticancer Nanodrugs".CHEMISTRY-AN ASIAN JOURNAL (2020):16.
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