On-line monitoring of the sol-gel transition temperature of thermosensitive chitosan/beta-glycerophosphate hydrogels by low field NMR

doi:10.1016/j.carbpol.2020.116196

CAS OpenIR

	On-line monitoring of the sol-gel transition temperature of thermosensitive chitosan/beta-glycerophosphate hydrogels by low field NMR
	Chen, Fangyu 1,2; Chen, Chao 1; Zhao, Dawei 1; Zhang, Songping 1; Ma, Guanghui 1; Su, Zhiguo 1; Li, Xiunan 1
	2020-06-15
Source Publication	CARBOHYDRATE POLYMERS
ISSN	0144-8617
Volume	238 Pages:8
Abstract	A temperature controlled low field nuclear magnetic resonance (LF-NMR) T-2 relaxometry technique based on the mobility changes of water trapped in hydrogels, was successfully used for on-line determination of the sol-gel transition temperature for chitosan/beta-glycerophosphate (CS/GP) hydrogels in real time. The LF-NMR results indicated that the gelation temperature decreased gradually with increasing GP concentration, and the results were supported by both thermogravimetric differential scanning calorimetry (DSC) and rheological findings; however, LF-NMR allows non-destructive monitoring of samples during continuous heating. Moreover, as the mobility of water molecules varies greatly during the sol-gel phase transition, the LF-NMR measurement was more sensitive and accurate (RSD <= 0.1 %, n = 5) compared with DSC (RSD: 1.2 %-3.7 %, n = 5) and rheology (RSD: 1.1 %-2.3 %, n = 5).
Keyword	Temperature sensitivity Chitosan Hydrogel Sol-gel LF-NMR Temperature control
DOI	10.1016/j.carbpol.2020.116196
Language	英语
WOS Keyword	KAPPA-CARRAGEENAN ; WATER MOBILITY ; RHEOLOGICAL PROPERTIES ; SUSTAINED DELIVERY ; THERMAL-STABILITY ; DRUG-DELIVERY ; IN-VITRO ; GELATION ; RELEASE ; RELAXATION
Funding Project	National Natural Sciences Foundation of China[21821005] ; National Natural Sciences Foundation of China[21376248] ; National Natural Sciences Foundation of China[21506228]
WOS Research Area	Chemistry ; Polymer Science
WOS Subject	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
Funding Organization	National Natural Sciences Foundation of China
WOS ID	WOS:000526413700022
Publisher	ELSEVIER SCI LTD
Citation statistics
Document Type	期刊论文
Identifier	http://ir.ipe.ac.cn/handle/122111/40003
Collection	中国科学院过程工程研究所
Corresponding Author	Su, Zhiguo; Li, Xiunan
Affiliation	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
Recommended Citation GB/T 7714	Chen, Fangyu,Chen, Chao,Zhao, Dawei,et al. On-line monitoring of the sol-gel transition temperature of thermosensitive chitosan/beta-glycerophosphate hydrogels by low field NMR[J]. CARBOHYDRATE POLYMERS,2020,238:8.
APA	Chen, Fangyu.,Chen, Chao.,Zhao, Dawei.,Zhang, Songping.,Ma, Guanghui.,...&Li, Xiunan.(2020).On-line monitoring of the sol-gel transition temperature of thermosensitive chitosan/beta-glycerophosphate hydrogels by low field NMR.CARBOHYDRATE POLYMERS,238,8.
MLA	Chen, Fangyu,et al."On-line monitoring of the sol-gel transition temperature of thermosensitive chitosan/beta-glycerophosphate hydrogels by low field NMR".CARBOHYDRATE POLYMERS 238(2020):8.

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