CAS OpenIR
Enhancement of transdermal delivery of artemisinin using microemulsion vehicle based on ionic liquid and lidocaine ibuprofen
Zhang, Yongqiang1,2; Cao, Yingying1,2; Meng, Xiangzhan1; Li, Chunshan1,2; Wang, Hui1,2; Zhang, Suojiang1,2
2020-05-01
Source PublicationCOLLOIDS AND SURFACES B-BIOINTERFACES
ISSN0927-7765
Volume189Pages:8
AbstractA microemulsion system based on ionic liquid (IL) and deep eutectic compound was proposed to improve the transdermal delivery of artemisinin. Deep eutectic lidocaine ibuprofen (Lid center dot Ibu) was selected as the oil phase, and the imidazolium ionic liquid, 1-hydroxyethyl-3-methylimidazolium chloride ([HOEmim]Cl), was incorporated into the aqueous phase as a transdermal enhancer. The ingredients for the microemulsion in this study were selected, and their ratios were optimized. The optimal microemulsion carrier was composed of 45 wt % of water phase, 45 wt% surfactant phase (containing Tween-80, Span-20, and ethanol (co-surfactant) with the weight ratio of 1:1:1), and 10 wt% Lid center dot Ibu as the oil phase with artemisinin loading of 1.0 wt% (all the ratios were based on the total weight of microemulsion). Physical properties of this microemulsion, including particle size (41.95 +/- 0.85 nm), viscosity (26.65 +/- 0.13 mPa center dot s) and density (1.02 g/cm(3)), were measured. In-vitro transdermal assay showed a remarkable enhancement of artemisinin transport through the skin, with the permeation flux being 3-fold of the value for isopropyl myristate system in 6 h. The impact of IL-based microemulsion (ILME) on stratum corneum (SC) was investigated by DSC, ATR-FTIR and AFM, which unveiled that the ILME possesses the ability of reducing the SC barrier by disrupting the regular arrangement of keratin, resulting in enhancement of transdermal delivery of artemisinin. This current work suggested that the microemulsion proposed here had an excellent capability to promote the transdermal delivery of artemisinin, which might also be a promising vehicle for the skin delivery of other hydrophobic natural drugs.
KeywordArtemisinin Microemulsion Ionic liquid Lid center dot Ibu Transdermal delivery
DOI10.1016/j.colsurfb.2020.110886
Language英语
WOS KeywordANTIMALARIAL-DRUG ; IN-VITRO ; PERMEATION ; SKIN ; EXTRACTION ; BIOAVAILABILITY ; CYCLODEXTRIN ; FORMULATION ; SYSTEM ; MEDIA
Funding ProjectInnovation Academy for Green Manufacture, Chinese Academy of Sciences[IAGM-2019A12] ; CAS Pioneer Hundred Talents Program, National Natural Science Foundation of China[21878311] ; Major Program of National Natural Science Foundation of China[21890762] ; K. C. Wong Education Foundation[GJTD-2018-04]
WOS Research AreaBiophysics ; Chemistry ; Materials Science
WOS SubjectBiophysics ; Chemistry, Physical ; Materials Science, Biomaterials
Funding OrganizationInnovation Academy for Green Manufacture, Chinese Academy of Sciences ; CAS Pioneer Hundred Talents Program, National Natural Science Foundation of China ; Major Program of National Natural Science Foundation of China ; K. C. Wong Education Foundation
WOS IDWOS:000527314700053
PublisherELSEVIER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/40335
Collection中国科学院过程工程研究所
Corresponding AuthorWang, Hui; Zhang, Suojiang
Affiliation1.Chinese Acad Sci, Innovat Acad Green Manufacture, CAS Key Lab Green Proc & Engn,Beijing Key Lab Ion, State Key Lab Multiphase Complex Syst,Inst Proc E, 1 Beierjie, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sino Danish Coll, Yanqihu Campus,380 Huaibeizhuang, Beijing 101408, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yongqiang,Cao, Yingying,Meng, Xiangzhan,et al. Enhancement of transdermal delivery of artemisinin using microemulsion vehicle based on ionic liquid and lidocaine ibuprofen[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2020,189:8.
APA Zhang, Yongqiang,Cao, Yingying,Meng, Xiangzhan,Li, Chunshan,Wang, Hui,&Zhang, Suojiang.(2020).Enhancement of transdermal delivery of artemisinin using microemulsion vehicle based on ionic liquid and lidocaine ibuprofen.COLLOIDS AND SURFACES B-BIOINTERFACES,189,8.
MLA Zhang, Yongqiang,et al."Enhancement of transdermal delivery of artemisinin using microemulsion vehicle based on ionic liquid and lidocaine ibuprofen".COLLOIDS AND SURFACES B-BIOINTERFACES 189(2020):8.
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