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| Double Emulsion-Templated Single-Core PLGA Microcapsules with Narrow Size Distribution and Controllable Structure by Using Premix Membrane Emulsification | |
| Na, Xiangming1; Guo, Jianjun2; Li, Tong2; Zhou, Weiqing1,3; Ma, Guanghui1 | |
| 2020-04-29 | |
| Source Publication | CHEMNANOMAT
 |
| ISSN | 2199-692X |
| Pages | 5 |
| Abstract | A scalable and versatile strategy was developed for fabrication of double emulsion-templated single-core PLGA microcapsules with narrow size distribution and controllable structure. A single-core water-in-oil-in-water (W-1/O/W-2) double emulsion was generated from two-step premix membrane emulsification, which guaranteed the narrow size distribution and size controllability of emulsion. During a secondary emulsification process, coalescence of W-1 droplets within oil droplet allowed multi-core W-1/O/W-2 double emulsion to spontaneously transform to a single-core one. The osmotic pressure and solvent diffusion rate were used to control the shell-thickness and surface morphology of single-core PLGA microcapsules, respectively. The method proposed in this study could be extended for the fabrication of uniform single-core polymeric microcapsules with controllable structures and size. |
| Keyword | Double emulsion Membrane emulsification Single-core microcapsule Controllable structures |
| DOI | 10.1002/cnma.202000175 |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[21902160] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16020405] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS Subject | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| Funding Organization | National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| WOS ID | WOS:000529198200001 |
| Publisher | WILEY-V C H VERLAG GMBH |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/40394 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Zhou, Weiqing; Ma, Guanghui |
| Affiliation | 1.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Stem Cell & Regenerat, 1 North 2nd St, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Na, Xiangming,Guo, Jianjun,Li, Tong,et al. Double Emulsion-Templated Single-Core PLGA Microcapsules with Narrow Size Distribution and Controllable Structure by Using Premix Membrane Emulsification[J]. CHEMNANOMAT,2020:5. |
| APA | Na, Xiangming,Guo, Jianjun,Li, Tong,Zhou, Weiqing,&Ma, Guanghui.(2020).Double Emulsion-Templated Single-Core PLGA Microcapsules with Narrow Size Distribution and Controllable Structure by Using Premix Membrane Emulsification.CHEMNANOMAT,5. |
| MLA | Na, Xiangming,et al."Double Emulsion-Templated Single-Core PLGA Microcapsules with Narrow Size Distribution and Controllable Structure by Using Premix Membrane Emulsification".CHEMNANOMAT (2020):5. |
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