CAS OpenIR
A self-driven bioinspired nanovehicle by leukocyte membrane-hitchhiking for early detection and treatment of atherosclerosis
Wu, Guanghao1; Wei, Wei2; Zhang, Jinfeng1; Nie, Weidong1; Yuan, Lan3; Huang, Yuanyu1; Zuo, Liping1; Huang, Lili1; Xi, Xiaobo2; Xie, Hai-Yan1
2020-08-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume250Pages:13
Abstract

Atherosclerosis, as a silent killer, remains one of the most common causes of human morbidity and mortality worldwide due to the lack of efficient strategy for early detection and targeted therapy. In this work, a self-driven bioinspired nanovehicle is developed, which can accurately manage early atherosclerosis with simultaneously multiple-targeting, dual-modality therapy as well as noninvasive magnetic resonance imaging (MRI). The magnetic nanoclusters (MNCs) with satisfactory superparamagnetism are camouflaged with leukocyte membranes, thus acquiring inherently targeting and transmigrating capabilities to intimal foam cells in early atherosclerotic lesions, which is validated using tailor-made microfluidic devices and transwell assays. Upon sequentially embedding an anti-inflammatory drug simvastatin (ST) and decorating a targetable apolipoprotein A-I mimetic 4F peptide (AP), the as-fabricated MNC@M-ST/AP exhibits excellent anti-atherosclerotic effects by alleviating inflammation and oxidative stress as well as promoting cholesterol efflux via RCT pathways. This bioinspired leukocyte membrane-hitchhiking strategy will open new perspectives for the future clinical translations of biocompatible nanosystem in early detection and treatment of atherosclerosis.

KeywordSelf-driven Bioinspired Leukocyte Membranes Inflammation-chemotaxis Atherosclerosis
DOI10.1016/j.biomaterials.2020.119963
Language英语
WOS KeywordDensity-lipoproteins ; Pathogenesis ; Macrophages ; Nanoparticles ; Nanomedicine ; Magnetosomes ; Cells
Funding ProjectNational Natural Science Foundation of China[81571813] ; National Natural Science Foundation of China[21874011] ; National Natural Science Foundation of China[21622608] ; National Science and Technology Major Project[2018ZX 10301405-001]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
Funding OrganizationNational Natural Science Foundation of China ; National Science and Technology Major Project
WOS IDWOS:000530752200001
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/40436
Collection中国科学院过程工程研究所
Corresponding AuthorXie, Hai-Yan
Affiliation1.Beijing Inst Technol, Sch Life Sci, 5 South Zhong Guan Cun St, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China
3.Peking Univ, Med & Hlth Anal Ctr, Xueyuan Rd, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Wu, Guanghao,Wei, Wei,Zhang, Jinfeng,et al. A self-driven bioinspired nanovehicle by leukocyte membrane-hitchhiking for early detection and treatment of atherosclerosis[J]. BIOMATERIALS,2020,250:13.
APA Wu, Guanghao.,Wei, Wei.,Zhang, Jinfeng.,Nie, Weidong.,Yuan, Lan.,...&Xie, Hai-Yan.(2020).A self-driven bioinspired nanovehicle by leukocyte membrane-hitchhiking for early detection and treatment of atherosclerosis.BIOMATERIALS,250,13.
MLA Wu, Guanghao,et al."A self-driven bioinspired nanovehicle by leukocyte membrane-hitchhiking for early detection and treatment of atherosclerosis".BIOMATERIALS 250(2020):13.
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