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Biomimic strategies for modulating the interaction between particle adjuvants and antigen-presenting cells | |
Wu, Jie1,2,3; Ma, Guanghui1,2,3,4 | |
2020-05-07 | |
Source Publication | BIOMATERIALS SCIENCE
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ISSN | 2047-4830 |
Volume | 8Issue:9Pages:2366-2375 |
Abstract | Developing effective adjuvants is becoming increasingly important for the research of vaccine formulations. The addition of adjuvants could enhance the immune response, reduce the antigen dosage and prolong the protection time. In recent years, biomimetic strategies have been adopted in the design of vaccine adjuvants to achieve better immune protection efficiency. Particularly those particle adjuvants, which could easily mimic the physical and chemical properties of natural pathogens such as morphology and charge, have been developed. This review focuses on the study of bionic particle adjuvants, especially the effect of those particles' properties on their interaction with antigen-presenting cells (APCs). By mimicking natural pathogens, these particles possess the ability to increase the cellular uptake of antigens, activate APCs, and promote the lysosomal escape of antigens. |
DOI | 10.1039/c9bm02098e |
Language | 英语 |
WOS Keyword | Vaccine Delivery ; Immune-responses ; Dendritic Cells ; Polymeric Nanoparticles ; Antitumor Immunity ; Cross-presentation ; Cellular Uptake ; In-vitro ; Shape ; Size |
Funding Project | National Key R&D Program of China[2018YFC0311303] ; National Natural Science Foundation of China (NSFC)[21576268] ; National Natural Science Foundation of China (NSFC)[21776287] ; National Natural Science Foundation of China (NSFC)[21821005] ; Key Research Program of the Chinese Academy of Sciences[KFZD-SW-218] ; International Cooperation Project of the Chinese Academy of Sciences[122111KYSB20180021] |
WOS Research Area | Materials Science |
WOS Subject | Materials Science, bioMaterials |
Funding Organization | National Key R&D Program of China ; National Natural Science Foundation of China (NSFC) ; Key Research Program of the Chinese Academy of Sciences ; International Cooperation Project of the Chinese Academy of Sciences |
WOS ID | WOS:000532529400002 |
Publisher | ROYAL SOC CHEMISTRY |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.ipe.ac.cn/handle/122111/40464 |
Collection | 中国科学院过程工程研究所 |
Corresponding Author | Ma, Guanghui |
Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 1001900, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 4.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Peoples R China |
Recommended Citation GB/T 7714 | Wu, Jie,Ma, Guanghui. Biomimic strategies for modulating the interaction between particle adjuvants and antigen-presenting cells[J]. BIOMATERIALS SCIENCE,2020,8(9):2366-2375. |
APA | Wu, Jie,&Ma, Guanghui.(2020).Biomimic strategies for modulating the interaction between particle adjuvants and antigen-presenting cells.BIOMATERIALS SCIENCE,8(9),2366-2375. |
MLA | Wu, Jie,et al."Biomimic strategies for modulating the interaction between particle adjuvants and antigen-presenting cells".BIOMATERIALS SCIENCE 8.9(2020):2366-2375. |
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Biomimic strategies (1310KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text |
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