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Biomimic strategies for modulating the interaction between particle adjuvants and antigen-presenting cells
Wu, Jie1,2,3; Ma, Guanghui1,2,3,4
2020-05-07
Source PublicationBIOMATERIALS SCIENCE
ISSN2047-4830
Volume8Issue:9Pages:2366-2375
Abstract

Developing effective adjuvants is becoming increasingly important for the research of vaccine formulations. The addition of adjuvants could enhance the immune response, reduce the antigen dosage and prolong the protection time. In recent years, biomimetic strategies have been adopted in the design of vaccine adjuvants to achieve better immune protection efficiency. Particularly those particle adjuvants, which could easily mimic the physical and chemical properties of natural pathogens such as morphology and charge, have been developed. This review focuses on the study of bionic particle adjuvants, especially the effect of those particles' properties on their interaction with antigen-presenting cells (APCs). By mimicking natural pathogens, these particles possess the ability to increase the cellular uptake of antigens, activate APCs, and promote the lysosomal escape of antigens.

DOI10.1039/c9bm02098e
Language英语
WOS KeywordVaccine Delivery ; Immune-responses ; Dendritic Cells ; Polymeric Nanoparticles ; Antitumor Immunity ; Cross-presentation ; Cellular Uptake ; In-vitro ; Shape ; Size
Funding ProjectNational Key R&D Program of China[2018YFC0311303] ; National Natural Science Foundation of China (NSFC)[21576268] ; National Natural Science Foundation of China (NSFC)[21776287] ; National Natural Science Foundation of China (NSFC)[21821005] ; Key Research Program of the Chinese Academy of Sciences[KFZD-SW-218] ; International Cooperation Project of the Chinese Academy of Sciences[122111KYSB20180021]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China (NSFC) ; Key Research Program of the Chinese Academy of Sciences ; International Cooperation Project of the Chinese Academy of Sciences
WOS IDWOS:000532529400002
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/40464
Collection中国科学院过程工程研究所
Corresponding AuthorMa, Guanghui
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 1001900, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
4.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Peoples R China
Recommended Citation
GB/T 7714
Wu, Jie,Ma, Guanghui. Biomimic strategies for modulating the interaction between particle adjuvants and antigen-presenting cells[J]. BIOMATERIALS SCIENCE,2020,8(9):2366-2375.
APA Wu, Jie,&Ma, Guanghui.(2020).Biomimic strategies for modulating the interaction between particle adjuvants and antigen-presenting cells.BIOMATERIALS SCIENCE,8(9),2366-2375.
MLA Wu, Jie,et al."Biomimic strategies for modulating the interaction between particle adjuvants and antigen-presenting cells".BIOMATERIALS SCIENCE 8.9(2020):2366-2375.
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