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Thioether-bridged mesoporous organosilica nanocapsules with weak acid-triggered charge reversal for drug delivery
Zhou, Mengyun1; Xing, Yi1; Li, Weike1; Li, Xiaoyu2; Zhang, Xueji1; Du, Xin1
2020-08-01
Source PublicationMICROPOROUS AND MESOPOROUS MATERIALS
ISSN1387-1811
Volume302Pages:10
AbstractThe drug delivery nanosystems with weak acid-triggered surface charge reversal function should be promising for efficient chemotherapy due to the prolonged blood circulation and enhanced the cellular uptake. However, there are only limited reports up to now. In this study, we fabricated a hybrid nanocapsule with a negative-to-positive charge-reversal outer layer triggered by the weak acidity in tumor microenvironment. The short branched polyethylenimine (PEI) with positive charge and weak acid-sensitive hexahydmphthalic anhydride with negative charge were successively modified on the surface of small uniform thioether-bridged hollow mesoporous silica nanospheres with multiple cavities. The modification of PEI as a linker was more favorable for charge reversal than that of aminopropyl group. The constructed hybrid nanocapsules exhibited weak acid (pH 6.0)-triggered charge reversal and drug release behaviors, thus effectively inhibiting the growth of A549 cancer cells. The surface functionalization of hybrid nanocapsules opens new opportunities for the development of silica-based hybrid nanosystems for promising drug delivery.
KeywordMesoporous organosilica Thioether-bridged framework Nanocapsules Charge reversal Drug delivery
DOI10.1016/j.micromeso.2020.110242
Language英语
WOS KeywordSILICA NANOPARTICLES ; SILSESQUIOXANE FRAMEWORK ; CONTROLLED-RELEASE ; EFFICIENT ; NANOHYBRIDS
Funding ProjectFundamental Research Funds for the Central Universities[FRF-TP-19-017B1] ; National Natural Science Foundation of China[21501009] ; National Natural Science Foundation of China[51671181] ; Beijing Municipal Science and Technology Commission[z131102002813058]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Applied ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationFundamental Research Funds for the Central Universities ; National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission
WOS IDWOS:000532052100046
PublisherELSEVIER
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/40468
Collection中国科学院过程工程研究所
Corresponding AuthorLi, Xiaoyu; Zhang, Xueji; Du, Xin
Affiliation1.Univ Sci & Technol Beijing, Res Ctr Bioengn & Sensing Technol, Dept Chem & Biol Engn, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Engn Lab Hydromet Cleaner Prod Technol, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Mengyun,Xing, Yi,Li, Weike,et al. Thioether-bridged mesoporous organosilica nanocapsules with weak acid-triggered charge reversal for drug delivery[J]. MICROPOROUS AND MESOPOROUS MATERIALS,2020,302:10.
APA Zhou, Mengyun,Xing, Yi,Li, Weike,Li, Xiaoyu,Zhang, Xueji,&Du, Xin.(2020).Thioether-bridged mesoporous organosilica nanocapsules with weak acid-triggered charge reversal for drug delivery.MICROPOROUS AND MESOPOROUS MATERIALS,302,10.
MLA Zhou, Mengyun,et al."Thioether-bridged mesoporous organosilica nanocapsules with weak acid-triggered charge reversal for drug delivery".MICROPOROUS AND MESOPOROUS MATERIALS 302(2020):10.
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