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Two-step tumor-targeting therapy via integrating metabolic lipid-engineering with in situ click chemistry
Lu, Guihong1; Zuo, Liping1; Zhang, Jinfeng1; Zhu, Houshun1; Zhuang, Wanru1; Wei, Wei2; Xie, Hai-Yan1
2020-04-21
Source PublicationBIOMATERIALS SCIENCE
ISSN2047-4830
Volume8Issue:8Pages:2283-2288
AbstractHighly efficient tumor-targeted therapy remains a great challenge due to the complexity and heterogeneity of tumor tissues. Herein, we developed an in vivo two-step tumor-targeting strategy by combining metabolic lipid-engineering with a stain-promoted azide-alkyne 1,3-dipolar cycloaddition (SPAAC) reaction, independent of the tumor microenvironment and cell phenotype. Firstly, exogenously-supplied azidoethyl-cholines (AECho) were metabolically incorporated into the cell membranes in tumor tissues through the intrinsic biosynthesis of phosphatidylcholine. The pre-inserted and accumulated azido groups (N-3) could subsequently serve as 'artificial chemical receptors' for the specific anchoring of dibenzocyclooctyne (DBCO) modified biomimetic nanoparticles (DBCO-RBCG@ICG) via in situ click chemistry, resulting in significantly enhanced tumor-targeting and then an improved photothermal therapy effect. Such a two-step targeting strategy based on these cutting-edge techniques provided new insights into the universal and precise functionalization of living tissues for site-specific drug delivery in the diagnosis and treatment of various diseases.
DOI10.1039/d0bm00088d
Language英语
WOS KeywordVIVO ; PHOSPHOLIPIDS ; HETEROGENEITY ; NANOPARTICLES ; MAGNETOSOMES ; PROTEINS ; DELIVERY ; BIOLOGY ; CELLS
Funding ProjectNational Natural Science Foundation of China[81571813] ; National Natural Science Foundation of China[21874011] ; National Science and Technology Major Project[2018ZX 10301405-001]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
Funding OrganizationNational Natural Science Foundation of China ; National Science and Technology Major Project
WOS IDWOS:000530471400017
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/40490
Collection中国科学院过程工程研究所
Corresponding AuthorXie, Hai-Yan
Affiliation1.Beijing Inst Technol, Sch Life Sci, 5 South Zhong Guan Cun St, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Lu, Guihong,Zuo, Liping,Zhang, Jinfeng,et al. Two-step tumor-targeting therapy via integrating metabolic lipid-engineering with in situ click chemistry[J]. BIOMATERIALS SCIENCE,2020,8(8):2283-2288.
APA Lu, Guihong.,Zuo, Liping.,Zhang, Jinfeng.,Zhu, Houshun.,Zhuang, Wanru.,...&Xie, Hai-Yan.(2020).Two-step tumor-targeting therapy via integrating metabolic lipid-engineering with in situ click chemistry.BIOMATERIALS SCIENCE,8(8),2283-2288.
MLA Lu, Guihong,et al."Two-step tumor-targeting therapy via integrating metabolic lipid-engineering with in situ click chemistry".BIOMATERIALS SCIENCE 8.8(2020):2283-2288.
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