CAS OpenIR
Preparation of hydroxyapatite with high surface area and dispersity templated on calcium carbonate in dipeptide hydrogels
Ma, Yuqi1; Wang, Anhe2; Li, Jieling2; Li, Qi2; Han, Qingquan2,3; Chen, Yang2,3; Wang, Shengtao2,3; Zheng, Xuefang1; Cao, Hongyu1,4; Bai, Shuo2
2020-07-05
Source PublicationCOLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
Volume596Pages:7
AbstractHydroxyapatite (HAP) is the main inorganic component of human skeletal tissue such as bone, teeth et al. Because of its excellent biocompatibility, biodegradability and mechanical properties, it is widely applied in the field of medicine, particularly in bone repairing and drug release. However, it is difficult to prepare HAP particles with good dispersity in aqueous solution and high surface area. To solve the issue, porous CaCO3 were taken as a template to prepare hydroxyapatite with good dispersity and high surface area assisted by a dipeptide hydrogel system. Experimental data show that the sequence of dipeptide has a great effect on the dispersity of hydroxyapatite particles, and the obtained hydroxyapatite has a same particle size with the template of CaCO3, and can be dispersed in an aqueous solution very well. Meanwhile porous hydroxyapatite particles have a large surface area benefiting the loading of model drugs, and illustrate enhanced cell internalization efficiency and low cytotoxicity, which can be used as a sustained-release drug carrier.
KeywordPorous CaCO3 Template Hydroxyapatite Dipeptide hydrogel Drug release
DOI10.1016/j.colsurfa.2020.124740
Language英语
WOS KeywordTISSUE REGENERATION ; TRANSFORMATION ; FABRICATION ; NANOPARTICLE ; CAPSULES ; FACILE
Funding ProjectNational Natural Science Foundation of China[21774132] ; National Natural Science Foundation of China[21703253] ; National Natural Science Foundation of China[21601025] ; National Natural Science Foundation of China[21571025] ; Project of Young Science and Technology Star of Dalian[2017RQ156]
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
Funding OrganizationNational Natural Science Foundation of China ; Project of Young Science and Technology Star of Dalian
WOS IDWOS:000531539800004
PublisherELSEVIER
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/40534
Collection中国科学院过程工程研究所
Corresponding AuthorWang, Anhe; Zheng, Xuefang; Cao, Hongyu; Bai, Shuo
Affiliation1.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China
4.Dalian Univ, Coll Life Sci & Biotechnol, Dalian 116622, Peoples R China
Recommended Citation
GB/T 7714
Ma, Yuqi,Wang, Anhe,Li, Jieling,et al. Preparation of hydroxyapatite with high surface area and dispersity templated on calcium carbonate in dipeptide hydrogels[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2020,596:7.
APA Ma, Yuqi.,Wang, Anhe.,Li, Jieling.,Li, Qi.,Han, Qingquan.,...&Bai, Shuo.(2020).Preparation of hydroxyapatite with high surface area and dispersity templated on calcium carbonate in dipeptide hydrogels.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,596,7.
MLA Ma, Yuqi,et al."Preparation of hydroxyapatite with high surface area and dispersity templated on calcium carbonate in dipeptide hydrogels".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 596(2020):7.
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