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Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences
Ren, Peng2,3; Li, Jingtao1; Zhao, Luyang2; Wang, Anhe2; Wang, Meiyue2; Li, Jieling2; Jian, Honglei2; Li, Xiaoou1; Yan, Xuehai2; Bai, Shuo2,3
2020-05-13
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume12Issue:19Pages:21433-21440
AbstractDipeptide self-assembled hydrogels have potential biomedical applications because of their great biocompatibility, bioactivity, and tunable physicochemical properties, which can be modulated in the molecular level by design of amino acid sequences. Herein, a series of dipeptides (Fmoc-FL, -YL, -LL, and -YA) are designed to form shear-thinning hydrogels with self-healing and tunable mechanical properties by adjusting the synergetic effect of hydrophobic interactions (p-p stacking and hydrophobic effect) and hydrogen bonds of peptides through substitution of amino acid residues. The enhancement of hydrophobic interactions is a primary factor to promote mechanical rigidity of hydrogels, and strong hydrogen-bonding interactions between molecules contribute to the instantaneous self-healing property, which is supported by experimental studies (FTIR, CD, SEM, AFM, and rheology) and molecular dynamics simulations. The injectable dipeptide hydrogels were certified as an ideal endoscopic submucosal dissection filler to make operation convenient and secure in mice and living mini-pig's experiments with a longer duration time, higher stiffness, and lower inflammatory response than commercial clinical fillers.
Keyworddipeptide self-assembly shear-thinning hydrogel self-healing endoscopic submucosal dissection
DOI10.1021/acsami.0c03038
Language英语
WOS KeywordBETA-SHEET ; DESIGN ; FABRICATION ; TRANSITION ; GELATION
Funding ProjectNational Natural Science Foundation of China[21774132] ; National Natural Science Foundation of China[21703253] ; China-Japan Friendship Hospital Research funding[2016-1-MS-5] ; Open Funding Project of the State Key Laboratory of Biochemical Engineering[2019KF-02]
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; China-Japan Friendship Hospital Research funding ; Open Funding Project of the State Key Laboratory of Biochemical Engineering
WOS IDWOS:000535246100026
PublisherAMER CHEMICAL SOC
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/40852
Collection中国科学院过程工程研究所
Corresponding AuthorLi, Jingtao; Bai, Shuo
Affiliation1.China Japan Friendship Hosp, Dept Gastroenterol, Beijing 100029, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Ren, Peng,Li, Jingtao,Zhao, Luyang,et al. Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12(19):21433-21440.
APA Ren, Peng.,Li, Jingtao.,Zhao, Luyang.,Wang, Anhe.,Wang, Meiyue.,...&Bai, Shuo.(2020).Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences.ACS APPLIED MATERIALS & INTERFACES,12(19),21433-21440.
MLA Ren, Peng,et al."Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences".ACS APPLIED MATERIALS & INTERFACES 12.19(2020):21433-21440.
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