CAS OpenIR
Boron-based nanosheets for combined cancer photothermal and photodynamic therapy
Kang, Yong1,2; Ji, Xiaoyuan3; Li, Zhengjun1; Su, Zhiguo1; Zhang, Songping1
2020-06-07
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume8Issue:21Pages:4609-4619
Abstract

Tumor phototherapy is of great significance for the expansion and advancement of cancer treatment methods. Herein, two-dimensional boron nanosheets (B NSs) with a thickness of 2.4 nm exhibiting an excellent photothermal conversion performance were developed via a simple liquid phase ultrasonic stripping method. Following the loading of the photosensitizer agent chlorin e6 (Ce6) and subsequent modification with poly(allylamine hydrochloride) (PAH) and poly(acrylic acid) (PAA), a B@Ce6-PAH-PAA NS nanomedicine exhibiting dual modal imaging-guided cancer photothermal therapy (PTT) and photodynamic therapy (PDT) properties, as well as outstanding stability was developed. The suitable nano-size (120 nm) of B@Ce6-PAH-PAA NSs can allow drugs to target tumor tissue with an enhanced permeability and retention effect (EPR). The cytotoxicity experiments demonstrated that B@Ce6-PAH-PAA NSs exhibited good biocompatibility even at high concentrations. Furthermore, the in vitro and in vivo experiments showed the excellent synergistic therapeutic effect of this nanomedicine for PTT and PDT.

DOI10.1039/d0tb00070a
Language英语
WOS KeywordWs2 Nanosheets ; Phosphorus ; Exfoliation ; Borophene ; Growth
Funding ProjectNational Natural Science Foundation of China[21676276] ; National Natural Science Foundation of China[81801826] ; Science, Technology & Innovation Commission of Shenzhen Municipality[JCYJ20180307153300735]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
Funding OrganizationNational Natural Science Foundation of China ; Science, Technology & Innovation Commission of Shenzhen Municipality
WOS IDWOS:000538170900005
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/40898
Collection中国科学院过程工程研究所
Corresponding AuthorJi, Xiaoyuan; Zhang, Songping
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
3.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Guangzhou 510275, Peoples R China
Recommended Citation
GB/T 7714
Kang, Yong,Ji, Xiaoyuan,Li, Zhengjun,et al. Boron-based nanosheets for combined cancer photothermal and photodynamic therapy[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(21):4609-4619.
APA Kang, Yong,Ji, Xiaoyuan,Li, Zhengjun,Su, Zhiguo,&Zhang, Songping.(2020).Boron-based nanosheets for combined cancer photothermal and photodynamic therapy.JOURNAL OF MATERIALS CHEMISTRY B,8(21),4609-4619.
MLA Kang, Yong,et al."Boron-based nanosheets for combined cancer photothermal and photodynamic therapy".JOURNAL OF MATERIALS CHEMISTRY B 8.21(2020):4609-4619.
Files in This Item:
File Name/Size DocType Version Access License
Boron-based nanoshee(5651KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Kang, Yong]'s Articles
[Ji, Xiaoyuan]'s Articles
[Li, Zhengjun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Kang, Yong]'s Articles
[Ji, Xiaoyuan]'s Articles
[Li, Zhengjun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Kang, Yong]'s Articles
[Ji, Xiaoyuan]'s Articles
[Li, Zhengjun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.