CAS OpenIR
Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination
Xi, Xiaobo2; Ye, Tong1,2; Wang, Shuang1; Na, Xiangming1; Wang, Jianghua1,2; Qing, Shuang1,2; Gao, Xiaoyong1; Wang, Changlong1,2; Li, Feng1,2; Wei, Wei1,2; Ma, Guanghui1,2
2020-05-01
Source PublicationSCIENCE ADVANCES
ISSN2375-2548
Volume6Issue:21Pages:16
AbstractTherapeutic cancer vaccines that harness the immune system to reject cancer cells have shown great promise for cancer treatment. Although a wave of efforts have spurred to improve the therapeutic effect, unfavorable immunization microenvironment along with a complicated preparation process and frequent vaccinations substantially compromise the performance. Here, we report a novel microcapsule-based formulation for high-performance cancer vaccinations. The special self-healing feature provides a mild and efficient paradigm for antigen microencapsulation. After vaccination, these microcapsules create a favorable immunization microenvironment in situ, wherein antigen release kinetics, recruited cell behavior, and acid surrounding work in a synergetic manner. In this case, we can effectively increase the antigen utilization, improve the antigen presentation, and activate antigen presenting cells. As a result, effective T cell response, potent tumor inhibition, antimetastatic effects, and prevention of postsurgical recurrence are achieved with various types of antigens, while neoantigen was encapsuled and evaluated in different tumor models.
DOI10.1126/sciadv.aay7735
Language英语
WOS KeywordSYNTHETIC VACCINES ; IMMUNE-RESPONSES ; DENDRITIC CELLS ; DELIVERY ; IMMUNOTHERAPY ; ANTIGENS ; MICROENCAPSULATION ; NANOPARTICLES ; ENCAPSULATION ; ADJUVANTS
Funding ProjectNational Key R&D Program of China[2017YFA0207900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] ; National Natural Science Foundation of China[21622608] ; National Natural Science Foundation of China[21821005]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
Funding OrganizationNational Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China
WOS IDWOS:000537235300007
PublisherAMER ASSOC ADVANCEMENT SCIENCE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/40981
Collection中国科学院过程工程研究所
Corresponding AuthorWei, Wei; Ma, Guanghui
Affiliation1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Xi, Xiaobo,Ye, Tong,Wang, Shuang,et al. Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination[J]. SCIENCE ADVANCES,2020,6(21):16.
APA Xi, Xiaobo.,Ye, Tong.,Wang, Shuang.,Na, Xiangming.,Wang, Jianghua.,...&Ma, Guanghui.(2020).Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination.SCIENCE ADVANCES,6(21),16.
MLA Xi, Xiaobo,et al."Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination".SCIENCE ADVANCES 6.21(2020):16.
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