CAS OpenIR
Immunomodulation-Enhanced Nanozyme-Based Tumor Catalytic Therapy
Xu, Bolong1; Cui, Yan1,2; Wang, Weiwei1; Li, Shanshan1; Lyu, Chengliang2; Wang, Shuang2; Bao, Weier2; Wang, Hongyu1; Qin, Meng1; Liu, Zhen1; Wei, Wei2; Liu, Huiyu1
2020-07-06
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Pages10
AbstractNanozyme-based tumor catalytic therapy has attracted widespread attention in recent years. However, its therapeutic outcomes are diminished by many factors in the tumor microenvironment (TME), such as insufficient endogenous hydrogen peroxide (H2O2) concentration, hypoxia, and immunosuppressive microenvironment. Herein, an immunomodulation-enhanced nanozyme-based tumor catalytic therapy strategy is first proposed to achieve the synergism between nanozymes and TME regulation. TGF-beta inhibitor (TI)-loaded PEGylated iron manganese silicate nanoparticles (IMSN) (named as IMSN-PEG-TI) are constructed to trigger the therapeutic modality. The results show that IMSN nanozyme exhibits both intrinsic peroxidase-like and catalase-like activities under acidic TME, which can decompose H(2)O(2)into hydroxyl radicals (center dot OH) and oxygen (O-2), respectively. Besides, it is demonstrated that both IMSN and TI can regulate the tumor immune microenvironment, resulting in macrophage polarization from M2 to M1, and thus inducing the regeneration of H2O2, which can promote catalytic activities of IMSN nanozyme. The potent antitumor effect of IMSN-PEG-TI is proved by in vitro multicellular tumor spheroids (MCTS) and in vivo CT26-tumor-bearing mice models. It is believed that the immunomodulation-enhanced nanozyme-based tumor treatment strategy is a promising tool to kill cancer cells.
Keywordcatalase-like activity immunomodulation nanozymes peroxidase-like activity tumor catalytic therapy
DOI10.1002/adma.202003563
Language英语
WOS KeywordMACROPHAGE POLARIZATION ; CANCER ; NANOPARTICLES ; GROWTH ; INHIBITION ; GRAPHENE ; CHEMOTHERAPY ; NANOCATALYST ; PHENOTYPE ; CELL
Funding ProjectNational Natural Science Foundation of China[21822802] ; National Natural Science Foundation of China[21622608] ; National Natural Science Foundation of China[51772018] ; National Natural Science Foundation of China[51572271] ; National Key Research and Development Program of China[2016YFA0201500] ; National Key Research and Development Program of China[2017YFA0207900] ; Fundamental Research Funds for the Central University[buctrc201915] ; Fundamental Research Funds for the Central University[XK1802-8]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Natural Science Foundation of China ; National Key Research and Development Program of China ; Fundamental Research Funds for the Central University
WOS IDWOS:000545735200001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41311
Collection中国科学院过程工程研究所
Corresponding AuthorWei, Wei; Liu, Huiyu
Affiliation1.Beijing Univ Chem Technol, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, State Key Lab Organ Inorgan Composites, Beijing Key Lab Bioproc,Beijing Lab Biomed Mat,Bi, Beijing 100029, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xu, Bolong,Cui, Yan,Wang, Weiwei,et al. Immunomodulation-Enhanced Nanozyme-Based Tumor Catalytic Therapy[J]. ADVANCED MATERIALS,2020:10.
APA Xu, Bolong.,Cui, Yan.,Wang, Weiwei.,Li, Shanshan.,Lyu, Chengliang.,...&Liu, Huiyu.(2020).Immunomodulation-Enhanced Nanozyme-Based Tumor Catalytic Therapy.ADVANCED MATERIALS,10.
MLA Xu, Bolong,et al."Immunomodulation-Enhanced Nanozyme-Based Tumor Catalytic Therapy".ADVANCED MATERIALS (2020):10.
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