CAS OpenIR
Coassembly-Induced Transformation of Dipeptide Amyloid-Like Structures into Stimuli-Responsive Supramolecular Materials
Ji, Wei3; Yuan, Chengqian2; Chakraborty, Priyadarshi3; Makam, Pandeeswar3; Bera, Santu3; Rencus-Lazar, Sigal3; Li, Junbai1; Yan, Xuehai2; Gazit, Ehud3,4
2020-06-23
Source PublicationACS NANO
ISSN1936-0851
Volume14Issue:6Pages:7181-7190
AbstractConformational transition of proteins and peptides into highly stable, beta-sheet-rich structures is observed in many amyloid-associated neurodegenerative disorders, yet the precise mechanism of amyloid formation at the molecular level remains poorly understood due to the complex molecular structures. Short peptides provide simplified models for studying the molecular basis of the assembly mechanism that governs beta-sheet fibrillation processes underlying the formation and inhibition of amyloid-like structures. Herein, we report a supramolecular coassembly strategy for the inhibition and transformation of stable beta-sheet-rich amyloid-derived dipeptide self-assemblies into adaptable secondary structural fibrillar assemblies by mixing with bipyridine derivatives. The interplay between the type and mixing ratio of bipyridine derivatives allowed the variable coassembly process with stimuli-responsive functional properties, studied by various experimental characterizations and computational methods. Furthermore, the resulting coassemblies showed functional redox- and photoresponsive properties, making them promising candidates for controllable drug release and fluorescent imprint. This work presents a coassembly strategy not only to explore the mechanism of amyloid-like structure formation and inhibition at the molecular level but also to manipulate amyloid-like structures into responsive supramolecular coassemblies for material science and biotechnology applications.
Keywordamyloid-like structure self-assembly dipeptide stimuli-responsive supramolecular chemistry
DOI10.1021/acsnano.0c02138
Language英语
WOS KeywordBETA-SHEET ; PEPTIDE ASSEMBLIES ; ALPHA-HELIX ; DIPHENYLALANINE ; HYDROGELS ; FIBRILS ; NANOCARRIERS ; ORGANIZATION ; AGGREGATION ; TRANSITION
Funding ProjectEuropean Research Council under the European Union Horizon 2020 research and innovation program[694426] ; National Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21802144] ; National Natural Science Foundation of China[21802143] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationEuropean Research Council under the European Union Horizon 2020 research and innovation program ; National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)
WOS IDWOS:000543744100077
PublisherAMER CHEMICAL SOC
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41314
Collection中国科学院过程工程研究所
Corresponding AuthorLi, Junbai; Yan, Xuehai; Gazit, Ehud
Affiliation1.Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Tel Aviv Univ, Dept Mol Microbiol & Biotechnol, George S Wise Fac Life Sci, IL-6997801 Tel Aviv, Israel
4.Tel Aviv Univ, Dept Mat Sci & Engn, Iby & Aladar Fleischman Fac Engn, IL-6997801 Tel Aviv, Israel
Recommended Citation
GB/T 7714
Ji, Wei,Yuan, Chengqian,Chakraborty, Priyadarshi,et al. Coassembly-Induced Transformation of Dipeptide Amyloid-Like Structures into Stimuli-Responsive Supramolecular Materials[J]. ACS NANO,2020,14(6):7181-7190.
APA Ji, Wei.,Yuan, Chengqian.,Chakraborty, Priyadarshi.,Makam, Pandeeswar.,Bera, Santu.,...&Gazit, Ehud.(2020).Coassembly-Induced Transformation of Dipeptide Amyloid-Like Structures into Stimuli-Responsive Supramolecular Materials.ACS NANO,14(6),7181-7190.
MLA Ji, Wei,et al."Coassembly-Induced Transformation of Dipeptide Amyloid-Like Structures into Stimuli-Responsive Supramolecular Materials".ACS NANO 14.6(2020):7181-7190.
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