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The Toxicity and Polymorphism of beta-Amyloid Oligomers
Huang, Ya-ru1,2; Liu, Rui-tian1
2020-06-01
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume21Issue:12Pages:19
AbstractIt is widely accepted that beta-amyloid oligomers (A beta os) play a key role in the progression of Alzheimer's disease (AD) by inducing neuron damage and cognitive impairment, but A beta os are highly heterogeneous in their size, structure and cytotoxicity, making the corresponding studies tough to carry out. Nevertheless, a number of studies have recently made remarkable progress in the describing the characteristics and pathogenicity of A beta os. We here review the mechanisms by which A beta os exert their neuropathogenesis for AD progression, including receptor binding, cell membrane destruction, mitochondrial damage, Ca(2+)homeostasis dysregulation and tau pathological induction. We also summarize the characteristics and pathogenicity such as the size, morphology and cytotoxicity of dimers, trimers, A beta*56 and spherical oligomers, and suggest that A beta os may play a different role at different phases of AD pathogenesis, resulting in differential consequences on neuronal synaptotoxicity and survival. It is warranted to investigate the temporal sequence of A beta os in AD human brain and examine the relationship between different A beta os and cognitive impairment.
Keywordbeta-amyloid oligomers Alzheimer's disease polymorphism toxicity aggregation
DOI10.3390/ijms21124477
Language英语
WOS KeywordCELLULAR PRION PROTEIN ; A-BETA ; ALZHEIMERS-DISEASE ; SYNAPTIC PLASTICITY ; MOUSE MODEL ; COGNITIVE IMPAIRMENT ; TAU PHOSPHORYLATION ; ADRENERGIC-RECEPTOR ; PRECURSOR PROTEIN ; MEMORY DEFICITS
Funding ProjectNational Natural Science Foundation of China[81971610] ; National Natural Science Foundation of China[81971073]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China
WOS IDWOS:000550123500001
PublisherMDPI
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41440
Collection中国科学院过程工程研究所
Corresponding AuthorLiu, Rui-tian
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Huang, Ya-ru,Liu, Rui-tian. The Toxicity and Polymorphism of beta-Amyloid Oligomers[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2020,21(12):19.
APA Huang, Ya-ru,&Liu, Rui-tian.(2020).The Toxicity and Polymorphism of beta-Amyloid Oligomers.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(12),19.
MLA Huang, Ya-ru,et al."The Toxicity and Polymorphism of beta-Amyloid Oligomers".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21.12(2020):19.
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