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Minimal metallo-nanozymes constructed through amino acid coordinated self-assembly for hydrolase-like catalysis
Han, Jingjing1,2; Zou, Qianli1; Su, Weiwei1; Yan, Xuehai1,2,3
2020-08-15
Source PublicationCHEMICAL ENGINEERING JOURNAL
ISSN1385-8947
Volume394Pages:6
AbstractBioinspired nanozymes are promising in mimicking natural processes and developing function-enhanced architectures. However, constructing artificial enzyme systems with catalytic efficiencies rivaling that of natural enzymes in a minimal principle is challenging. Herein, we report the construction of minimal metallo-nanozymes through amino acid coordinated self-assembly by using amino acid derivatives and zinc (II) ions as the building blocks, reminiscent of the components of the catalytic architectures in natural hydrolases. The obtained metallonanozymes possess high and robust activity comparable to that of natural lipase in catalytically hydrolyzing phenyl acetate. In addition, catalytic performance of the metallo-nanozymes can be facilely optimized by changing the ratio between the building blocks and the introduction of additional biomolecules. The metallonanozymes also show catalytic activity in producing acetylsalicylic acid through the hydrolyzation of a prodrug, benorilate. This work highlights the minimal principle and excellent catalytic performance of stable metallonanozymes, opening up immense opportunities in the development of highly efficient nanozymes and catalytic prodrug conversion.
KeywordAmino acids Metal ion Self-assembly Metallo-nanozyme Catalytic hydrolyzation
DOI10.1016/j.cej.2020.124987
Language英语
WOS KeywordENZYME ; COMPLEXES ; HYDROLYSIS ; SITES
Funding ProjectNational Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21977095] ; National Natural Science Foundation of China[21821005] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; Youth Innovation Promotion Association CAS[2019051]
WOS Research AreaEngineering
WOS SubjectEngineering, Environmental ; Engineering, Chemical
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; Youth Innovation Promotion Association CAS
WOS IDWOS:000551901000047
PublisherELSEVIER SCIENCE SA
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41489
Collection中国科学院过程工程研究所
Corresponding AuthorYan, Xuehai
Affiliation1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Ctr Mesosci, Inst Proc Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Han, Jingjing,Zou, Qianli,Su, Weiwei,et al. Minimal metallo-nanozymes constructed through amino acid coordinated self-assembly for hydrolase-like catalysis[J]. CHEMICAL ENGINEERING JOURNAL,2020,394:6.
APA Han, Jingjing,Zou, Qianli,Su, Weiwei,&Yan, Xuehai.(2020).Minimal metallo-nanozymes constructed through amino acid coordinated self-assembly for hydrolase-like catalysis.CHEMICAL ENGINEERING JOURNAL,394,6.
MLA Han, Jingjing,et al."Minimal metallo-nanozymes constructed through amino acid coordinated self-assembly for hydrolase-like catalysis".CHEMICAL ENGINEERING JOURNAL 394(2020):6.
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