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Biodegradable functional chitosan membrane for enhancement of artemisinin purification
Cao, Yingying1,2; Zhang, Yongqiang1,2; Zhang, Ying1; Wang, Ling1; Lv, Lunchao3; Ma, Xifei1,2; Zeng, Shaojuan1; Wang, Hui1,2
2020-10-15
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume246Pages:11
AbstractArtemisinin is mainly derived from Artemisia annua L. Since the leaves composition is complex, artemisinin purification faces great challenges. In this work, functional chitosan membranes were fabricated by a one-step hydrolysis method through grafting long-chain alkyl group on the surface of chitosan to increase its hydro-phobicity. The as-prepared membranes were used to adsorb wax oil (i.e., the impurity components) in Artemisia annua L. and to avoid co-precipitation of wax oil along with artemisinin using the crystallization technique for purification. Octyl-trimethoxysilane modified chitosan membrane (FCM-C8) showed excellent capability to in-tensify this purification process. The product purity could reach more than 98 % using one crystallization step under the optimal conditions, and in this case, adsorption capacity of FCM-C8 for wax oil was 478.9 mg/g. In addition, the adsorption kinetics and mechanism of wax oil on FCM-C8 were studied. The membrane can si-multaneously adsorb multiple components in wax oil through interactions like electrostatic forces, hydrogen bondings.
KeywordFunctional chitosan membrane Artemisinin Purification Mechanism Kinetics
DOI10.1016/j.carbpol.2020.116590
Language英语
WOS KeywordDYE REMOVAL ; ACID DYES ; ADSORPTION ; FABRICATION ; EXTRACTION ; QUANTIFICATION ; EQUILIBRIUM ; FLAVONOIDS ; ADSORBENT ; CANCER
Funding ProjectNational Key R&D Program of China[2017YFB0603401-03] ; Innovation Academy for Green Manufacture, Chinese Academy of Sciences[IAGM-2019-A12] ; CAS Pioneer Hundred Talents Program ; K. C. Wong Education Foundation[GJTD-2018-04]
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
Funding OrganizationNational Key R&D Program of China ; Innovation Academy for Green Manufacture, Chinese Academy of Sciences ; CAS Pioneer Hundred Talents Program ; K. C. Wong Education Foundation
WOS IDWOS:000554907700014
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41578
Collection中国科学院过程工程研究所
Corresponding AuthorWang, Hui
Affiliation1.Chinese Acad Sci, Innovat Acad Green Manufacture, Beijing Key Lab Ion Liquids Clean Proc,Inst Proc, CAS Key Lab Green Proc & Engn,State Key Lab Multi, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Zhengzhou Univ, Sch Chem Engn, Zhengzhou 450001, Peoples R China
Recommended Citation
GB/T 7714
Cao, Yingying,Zhang, Yongqiang,Zhang, Ying,et al. Biodegradable functional chitosan membrane for enhancement of artemisinin purification[J]. CARBOHYDRATE POLYMERS,2020,246:11.
APA Cao, Yingying.,Zhang, Yongqiang.,Zhang, Ying.,Wang, Ling.,Lv, Lunchao.,...&Wang, Hui.(2020).Biodegradable functional chitosan membrane for enhancement of artemisinin purification.CARBOHYDRATE POLYMERS,246,11.
MLA Cao, Yingying,et al."Biodegradable functional chitosan membrane for enhancement of artemisinin purification".CARBOHYDRATE POLYMERS 246(2020):11.
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