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Recent research and development of local anesthetic-loaded microspheres
Wei, Yi1; Wu, Youbin2; Wen, Kang1,3; Bazybek, Nardana1,3; Ma, Guanghui1,3
2020-08-14
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume8Issue:30Pages:6322-6332
AbstractLocal anesthetic drugs are widely used in postoperative analgesia, local nerve block in surgery, and in the therapy of chronic pain. Due to their short half-time, a single administration of local anesthetics merely maintains the nerve block for several hours, which cannot meet the long-term analgesia effect needed in clinical treatment. In order to break through this limitation of local anesthetics, research work regarding controlled drug release from microspheres has attracted broad and current interest. This review introduces the recent research and development in local anesthetic-loaded microspheres for future clinical applications, where for an efficient microsphere formulation, the most critical aspects are an optimum preparation method, a high loading efficiency, and an ideal release rate. This review first summarizes the recent preparation methods of local anesthetic-loaded microspheres, which includes emulsion-solvent evaporation, spray-drying, microfluidic droplets, and premix membrane emulsification technology. Next, strategies for increasing the loading efficiency of the drug in microspheres are reviewed based on the solidification conditions, polymer properties, microsphere formulation, including the external water phase, pH, and polymer concentration. Finally, the effects of the preparation conditions, material characteristics, particle characteristics, and hydrogel/microsphere composite systems on the controlled release behavior are summarized.
DOI10.1039/d0tb01129k
Language英语
WOS KeywordNARROW SIZE DISTRIBUTION ; DRUG-DELIVERY SYSTEMS ; CONTROLLED-RELEASE ; PLGA MICROSPHERES ; IN-VITRO ; POLY(LACTIDE-CO-GLYCOLIDE) MICROSPHERES ; POSTOPERATIVE PAIN ; SUSTAINED-RELEASE ; BUPIVACAINE ; MICROPARTICLES
Funding ProjectNational Nature Science Foundation of China[21336010] ; National Key Technology Program[2017ZX09201004014]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
Funding OrganizationNational Nature Science Foundation of China ; National Key Technology Program
WOS IDWOS:000555679300002
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41607
Collection中国科学院过程工程研究所
Corresponding AuthorMa, Guanghui
Affiliation1.Chinese Acad Sci, State Key Lab Biochem Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Yichang Humanwell Pharmaceut Co Ltd, Yichang 443008, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wei, Yi,Wu, Youbin,Wen, Kang,et al. Recent research and development of local anesthetic-loaded microspheres[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(30):6322-6332.
APA Wei, Yi,Wu, Youbin,Wen, Kang,Bazybek, Nardana,&Ma, Guanghui.(2020).Recent research and development of local anesthetic-loaded microspheres.JOURNAL OF MATERIALS CHEMISTRY B,8(30),6322-6332.
MLA Wei, Yi,et al."Recent research and development of local anesthetic-loaded microspheres".JOURNAL OF MATERIALS CHEMISTRY B 8.30(2020):6322-6332.
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