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In vivoimmunological response of exposure to PEGylated graphene oxideviaintraperitoneal injection
Ding, Zhaowen1,2; Luo, Nana1,2; Yue, Hua1,2; Gao, Yongjun3; Ma, Guanghui1,2,4; Wei, Wei1,2
2020-08-21
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume8Issue:31Pages:6845-6856
AbstractPolyethylene glycol functionalization is believed to have the capacity of endowing nanomaterials with stealth characteristics, which can diminish the arrest by macrophages and adverse immunological response. However, our previous study provided evidences that polyethylene glycol-functionalized graphene oxide (GOP) stimulated a strong immunological response to macrophages despite non-internalizationin vitro, raising safety concerns and potential immunostimulation use of GOP. In light of this finding, we herein systematically study thein vivoimmunological response upon the exposure to GOPviaintraperitoneal injection. Taking cytokines production, cell types in the peritoneal fluid, biochemical index, hematology and histopathology asin vivoindicators, we demonstrate that GOP still remains the stealth-but-activating capacity on macrophages in a time and dose-dependent manner. Specifically, the immune response can be significantly elevated after a single high-dose injection, indicating that GOP can be a new candidate adjuvant for immunotherapy. For multiple low dose injections, the immune response is gentle, temporary, and tolerable, which manifests the biocompatibility of GOP in general drug delivery. The above results can thus provide guidance for safe and rational use of GOP for various biomedical applications.
DOI10.1039/d0tb00499e
Language英语
WOS KeywordGOLD NANOPARTICLES ; OXIDE ; FUNCTIONALIZATION ; NANOCOMPOSITES ; RECRUITMENT ; NEUTROPHIL ; TRANSITION ; DELIVERY ; SAFE ; IL-6
Funding ProjectNational Key R&D Program of China[2017YFA0207900] ; National Natural Science Foundation of China[21821005] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
WOS IDWOS:000558894300020
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41639
Collection中国科学院过程工程研究所
Corresponding AuthorMa, Guanghui; Wei, Wei
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
3.Hebei Univ, Coll Chem & Environm Sci, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 071002, Peoples R China
4.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Peoples R China
Recommended Citation
GB/T 7714
Ding, Zhaowen,Luo, Nana,Yue, Hua,et al. In vivoimmunological response of exposure to PEGylated graphene oxideviaintraperitoneal injection[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(31):6845-6856.
APA Ding, Zhaowen,Luo, Nana,Yue, Hua,Gao, Yongjun,Ma, Guanghui,&Wei, Wei.(2020).In vivoimmunological response of exposure to PEGylated graphene oxideviaintraperitoneal injection.JOURNAL OF MATERIALS CHEMISTRY B,8(31),6845-6856.
MLA Ding, Zhaowen,et al."In vivoimmunological response of exposure to PEGylated graphene oxideviaintraperitoneal injection".JOURNAL OF MATERIALS CHEMISTRY B 8.31(2020):6845-6856.
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