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| In vivoimmunological response of exposure to PEGylated graphene oxideviaintraperitoneal injection | |
| Ding, Zhaowen1,2; Luo, Nana1,2; Yue, Hua1,2; Gao, Yongjun3; Ma, Guanghui1,2,4; Wei, Wei1,2 | |
| 2020-08-21 | |
| Source Publication | JOURNAL OF MATERIALS CHEMISTRY B
 |
| ISSN | 2050-750X |
| Volume | 8Issue:31Pages:6845-6856 |
| Abstract | Polyethylene glycol functionalization is believed to have the capacity of endowing nanomaterials with stealth characteristics, which can diminish the arrest by macrophages and adverse immunological response. However, our previous study provided evidences that polyethylene glycol-functionalized graphene oxide (GOP) stimulated a strong immunological response to macrophages despite non-internalizationin vitro, raising safety concerns and potential immunostimulation use of GOP. In light of this finding, we herein systematically study thein vivoimmunological response upon the exposure to GOPviaintraperitoneal injection. Taking cytokines production, cell types in the peritoneal fluid, biochemical index, hematology and histopathology asin vivoindicators, we demonstrate that GOP still remains the stealth-but-activating capacity on macrophages in a time and dose-dependent manner. Specifically, the immune response can be significantly elevated after a single high-dose injection, indicating that GOP can be a new candidate adjuvant for immunotherapy. For multiple low dose injections, the immune response is gentle, temporary, and tolerable, which manifests the biocompatibility of GOP in general drug delivery. The above results can thus provide guidance for safe and rational use of GOP for various biomedical applications. |
| DOI | 10.1039/d0tb00499e |
| Language | 英语 |
| WOS Keyword | GOLD NANOPARTICLES ; OXIDE ; FUNCTIONALIZATION ; NANOCOMPOSITES ; RECRUITMENT ; NEUTROPHIL ; TRANSITION ; DELIVERY ; SAFE ; IL-6 |
| Funding Project | National Key R&D Program of China[2017YFA0207900] ; National Natural Science Foundation of China[21821005] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] |
| WOS Research Area | Materials Science |
| WOS Subject | Materials Science, Biomaterials |
| Funding Organization | National Key R&D Program of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| WOS ID | WOS:000558894300020 |
| Publisher | ROYAL SOC CHEMISTRY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/41639 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Ma, Guanghui; Wei, Wei |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 3.Hebei Univ, Coll Chem & Environm Sci, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 071002, Peoples R China 4.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Peoples R China |
| Recommended Citation GB/T 7714 | Ding, Zhaowen,Luo, Nana,Yue, Hua,et al. In vivoimmunological response of exposure to PEGylated graphene oxideviaintraperitoneal injection[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(31):6845-6856. |
| APA | Ding, Zhaowen,Luo, Nana,Yue, Hua,Gao, Yongjun,Ma, Guanghui,&Wei, Wei.(2020).In vivoimmunological response of exposure to PEGylated graphene oxideviaintraperitoneal injection.JOURNAL OF MATERIALS CHEMISTRY B,8(31),6845-6856. |
| MLA | Ding, Zhaowen,et al."In vivoimmunological response of exposure to PEGylated graphene oxideviaintraperitoneal injection".JOURNAL OF MATERIALS CHEMISTRY B 8.31(2020):6845-6856. |
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