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Iron nanoparticles augmented chemodynamic effect by alternative magnetic field for wound disinfection and healing
Gao, Fei1,2,4; Li, Xiaolian3; Zhang, Tingbin1; Ghosal, Anujit1; Zhang, Guifeng3; Fan, Hai Ming1; Zhao, Lingyun2
2020-08-10
Source PublicationJOURNAL OF CONTROLLED RELEASE
ISSN0168-3659
Volume324Pages:598-609
AbstractUtilizing the iron-carrying nanomaterials for Fenton chemistry mediation to catalyze decomposition of hydrogen peroxide and generate toxic hydroxyl radical (center dot OH) has drawn much attention in antimicrobial therapy field. However, these nanomaterials are usually with unsatisfactory catalytic efficacy and lack of the capacity to modulate the catalytic activity, which may give the bacteria opportunity in developing resistance against the antibacterial treatment. Herein, we systematically investigated the influence of alternating magnetic field (AMF) on the catalytic activity and antibacterial efficiency of the amorphous iron nanoparticles (AIronNPs). With rapidly ionized and the AMF augmented chemodynamic effect, the AIronNPs can convert low concentration of H2O2 into more center dot OH, the possible mechanism might be attributed to the accelerated ferrous iron ions releasing with AMF exposure. As a proof of concept, the AIronNPs and AMF synergetic antibacterial system have shown excellent broad-spectrum antimicrobial properties, 91.89% antibacterial efficiency is shown toward Escherichia coli and 92.65% toward Staphylococcus aureus. It also facilitated the formation of granulation tissue and accelerated wound healing on in vivo infected model, whereas AIronNPs alone have limited effect. We believe this work will broaden the thoughts for spatiotemporally manipulating the catalytic activity of nanomaterials and advance the development of magnetic nano-antibiotics in the antibacterial field.
KeywordAlternative magnetic field Amorphous iron nanoparticles Antibacterial Wound disinfection Chemodynamic
DOI10.1016/j.jconrel.2020.06.003
Language英语
WOS KeywordPEROXIDASE-LIKE ACTIVITY ; OXIDATIVE STRESS ; RESISTANCE ; CANCER ; NANOTECHNOLOGY ; RADICALS ; AGENT
Funding ProjectNational Natural Science Foundation of China[51971116] ; National Natural Science Foundation of China[81771981] ; National Natural Science Foundation of China[81671829]
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
Funding OrganizationNational Natural Science Foundation of China
WOS IDWOS:000558614500001
PublisherELSEVIER
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41702
Collection中国科学院过程工程研究所
Corresponding AuthorZhang, Guifeng; Fan, Hai Ming; Zhao, Lingyun
Affiliation1.Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710069, Shaanxi, Peoples R China
2.Tsinghua Univ, Sch Mat Sci & Engn, Key Lab Adv Mat, Minist Educ China, Beijing 100084, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Shaanxi Univ Chinese Med, Xian 712046, Shaanxi, Peoples R China
Recommended Citation
GB/T 7714
Gao, Fei,Li, Xiaolian,Zhang, Tingbin,et al. Iron nanoparticles augmented chemodynamic effect by alternative magnetic field for wound disinfection and healing[J]. JOURNAL OF CONTROLLED RELEASE,2020,324:598-609.
APA Gao, Fei.,Li, Xiaolian.,Zhang, Tingbin.,Ghosal, Anujit.,Zhang, Guifeng.,...&Zhao, Lingyun.(2020).Iron nanoparticles augmented chemodynamic effect by alternative magnetic field for wound disinfection and healing.JOURNAL OF CONTROLLED RELEASE,324,598-609.
MLA Gao, Fei,et al."Iron nanoparticles augmented chemodynamic effect by alternative magnetic field for wound disinfection and healing".JOURNAL OF CONTROLLED RELEASE 324(2020):598-609.
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