Knowledge Management System Of Institute of process engineering,CAS
| Coordination self-assembly of natural flavonoids into robust nanoparticles for enhanced in vitro chemo and photothermal cancer therapy | |
| Liu, Yilin1; Zhao, Luyang2; Shen, Guizhi2; Chang, Rui2,3; Zhang, Yi1; Yan, Xuehai2,3 | |
| 2020-08-05 | |
| Source Publication | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
 |
| ISSN | 0927-7757 |
| Volume | 598Pages:7 |
| Abstract | Utilizing small natural molecules from traditional Chinese medicines is highly promising and advantageous in curing diverse diseases. However, the clinical translation of many of these molecular drugs was hindered due to the vulnerable chemical structure and poor solubility. Herein, we reported a coordination-driven assembly strategy to synchronously enhance the stability and solubility of a typical natural molecular drug (luteolin) through the formation of nanoparticles. The resulting nanoparticles showed much enhanced solubility in physiological environment, broadened absorption spectrum to the near-infrared region, and high stability against oxidation. Intriguingly, the coordinated assembly with ferric ion introduces the supramolecular photothermal effects, enabling the nanoparticles to act as either a chemotherapeutic agent or a photothermal agent. This work represents that the coordination assembly strategy is facile and efficient for design of nanodrugs starting from naturally-derived molecular drugs and greatly enhance their therapeutic efficacy. |
| Keyword | Flavonoids Luteolin Coordination self-assembly Nanoparticles Cancer therapy |
| DOI | 10.1016/j.colsurfa.2020.124805 |
| Language | 英语 |
| WOS Keyword | LUTEOLIN ; DELIVERY ; PRODUCTS ; CELL |
| Funding Project | National Natural Science Foundation of China[51861145304] ; National Natural Science Foundation of China[21703252] ; National Natural Science Foundation of China[21802144] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Physical |
| Funding Organization | National Natural Science Foundation of China ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) |
| WOS ID | WOS:000561642700007 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/41737 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Shen, Guizhi; Zhang, Yi; Yan, Xuehai |
| Affiliation | 1.Cent South Univ, Coll Chem & Chem Engn, Hunan Prov Key Lab Micro & Nano Mat Interface Sci, Changsha 410083, Hunan, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North Second St, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Yilin,Zhao, Luyang,Shen, Guizhi,et al. Coordination self-assembly of natural flavonoids into robust nanoparticles for enhanced in vitro chemo and photothermal cancer therapy[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2020,598:7. |
| APA | Liu, Yilin,Zhao, Luyang,Shen, Guizhi,Chang, Rui,Zhang, Yi,&Yan, Xuehai.(2020).Coordination self-assembly of natural flavonoids into robust nanoparticles for enhanced in vitro chemo and photothermal cancer therapy.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,598,7. |
| MLA | Liu, Yilin,et al."Coordination self-assembly of natural flavonoids into robust nanoparticles for enhanced in vitro chemo and photothermal cancer therapy".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 598(2020):7. |
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