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A novel multiple emulsion enhanced immunityviaits biomimetic delivery approach
Zou, Yongjuan1,2; Wu, Nan1; Miao, Chunyu1; Yue, Hua1; Wu, Jie1,2,3,4; Ma, Guanghui1,2,3,4
2020-09-07
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume8Issue:33Pages:7365-7374
Abstract

To generate effective immunity post-vaccination, antigens need to be effectively captured and taken up by antigen-presenting cells (APCs) as a prerequisite. Biomimetic designs that mimic natural pathogen-like properties have provided platforms for antigen delivery. However, the structural dynamic properties of pathogens leading to their efficient internalization have been neglected in most platforms. Herein, we redesigned a special multiple emulsion with chitosan hydrogel nanoparticles inside, mimicking the configurational flexibility and deformational flexibility of pathogens. With the assistance of chitosan-antigen particles, the novel emulsion exhibited amplified deformability and the vaccine-cell contact zone was increased. Additionally, its configurational transitions, which offered sustained exposure of sheltered uptake signals including antigens and stimulator chitosan during endocytosis, resulted in efficient antigen delivery to APCs. Prolonged antigen depot effect, versatile antigen presentation, multiple immunocyte activation, and marked adjuvant-sparing effects were achieved as compared with those in the control groups. As a result, the intracellular emulsion formulation robustly induced both humoral and cellular immunity, especially CTL response, against the foot-and-mouth disease virus (FMDV) with improved biosafety. Our study highlights the positive impact of biomimetic structural dynamic properties on robust vaccine-cell interactions and provides a promising FMDV vaccine candidate.

DOI10.1039/d0tb01318h
Language英语
WOS KeywordImmune-responses ; Mouth-disease ; Adjuvant ; Oil ; Vaccination ; Antigen ; System ; Water ; Nanoparticles ; Particles
Funding ProjectNational Key R&D Program of China[2018YFC0311303] ; National Natural Science Foundation of China (NSFC)[21576268] ; National Natural Science Foundation of China (NSFC)[21776287] ; National Natural Science Foundation of China (NSFC)[21821005] ; Key Research Program of the Chinese Academy of Sciences[KFZD-SW-218] ; International Cooperation Project of the Chinese Academy of Sciences[122111KYSB20180021]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China (NSFC) ; Key Research Program of the Chinese Academy of Sciences ; International Cooperation Project of the Chinese Academy of Sciences
WOS IDWOS:000563148600003
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41760
Collection中国科学院过程工程研究所
Corresponding AuthorWu, Jie; Ma, Guanghui
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China
3.Chinese Acad Sci, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Inst Proc Engn, Beijing 100190, Peoples R China
4.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 210008, Peoples R China
Recommended Citation
GB/T 7714
Zou, Yongjuan,Wu, Nan,Miao, Chunyu,et al. A novel multiple emulsion enhanced immunityviaits biomimetic delivery approach[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(33):7365-7374.
APA Zou, Yongjuan,Wu, Nan,Miao, Chunyu,Yue, Hua,Wu, Jie,&Ma, Guanghui.(2020).A novel multiple emulsion enhanced immunityviaits biomimetic delivery approach.JOURNAL OF MATERIALS CHEMISTRY B,8(33),7365-7374.
MLA Zou, Yongjuan,et al."A novel multiple emulsion enhanced immunityviaits biomimetic delivery approach".JOURNAL OF MATERIALS CHEMISTRY B 8.33(2020):7365-7374.
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