Knowledge Management System Of Institute of process engineering,CAS
| Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis | |
| Wei, Peng1; Ye, Zhou1; Cao, Shuya1; Bai, Shuo4; Seeberger, Peter H.3; Yin, Jian1; Hu, Jing2 | |
| 2020-08-05 | |
| Source Publication | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
 |
| ISSN | 0927-7757 |
| Volume | 598Pages:7 |
| Abstract | Drugs used to treat visceral leishmaniasis (VL) have severe side effects and face increasing resistance. We have created a mannose-functionalized nanomicelle carrying two drugs amphotericin B (AmB) and doxorubicin (DOX). The nanomicelles AmB&DOX@MCC preferentially target macrophages where Leishmania parasites reside and replicate, by the interaction between mannose residues on the micelle and mannose receptors (MRs) on the macrophage membrane. The combination of AmB and DOX leads to enhanced anti-leishmanial therapeutic efficacy through a synergistic effect. The mannose-fabricated nanomicelle is a promising formulation for leishmaniasis treatment. |
| Keyword | Nanomicelle Leishmaniasis Mannose receptor |
| DOI | 10.1016/j.colsurfa.2020.124804 |
| Language | 英语 |
| WOS Keyword | IN-VITRO ; TARGETED DELIVERY ; HYBRID HYDROGELS ; INTERVENTION ; SYSTEM |
| Funding Project | National Natural Science Foundation of China[31700706] ; National Natural Science Foundation of China[21877052] ; Natural Science Foundation of Jiangsu Province[BK20180030] ; Fundamental Research Funds for the Central Universities[JUSRP51712B] ; Max Planck Society International Partner Group Program ; National Key R&D Program of China[2018YFA0901700] ; National First-class Discipline Program of Light Industry Technology and Engineering[LITE2018-14] ; China Scholarship Council ; Max-Planck Society |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Physical |
| Funding Organization | National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; Fundamental Research Funds for the Central Universities ; Max Planck Society International Partner Group Program ; National Key R&D Program of China ; National First-class Discipline Program of Light Industry Technology and Engineering ; China Scholarship Council ; Max-Planck Society |
| WOS ID | WOS:000561642700006 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/41771 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Yin, Jian; Hu, Jing |
| Affiliation | 1.Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Lihu Ave 1800, Wuxi, Jiangsu, Peoples R China 2.Jiangnan Univ, Wuxi Sch Med, Lihu Ave 1800, Wuxi 214122, Jiangsu, Peoples R China 3.Max Planck Inst Colloids & Interfaces, Dept Biomol Syst, D-14476 Potsdam, Germany 4.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Wei, Peng,Ye, Zhou,Cao, Shuya,et al. Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2020,598:7. |
| APA | Wei, Peng.,Ye, Zhou.,Cao, Shuya.,Bai, Shuo.,Seeberger, Peter H..,...&Hu, Jing.(2020).Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,598,7. |
| MLA | Wei, Peng,et al."Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 598(2020):7. |
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