CAS OpenIR
Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition
Lu, Zhiguo1,3; Wang, Jianze1; Qu, Lina2; Kan, Guanghan2; Zhang, Tianlu1,3; Shen, Jie1,3; Li, Yan1; Yang, Jun1; Niu, Yunwei4,5; Xiao, Zuobing4,5; Li, Yinghui2; Zhang, Xin1
2020-12-01
Source PublicationBIOACTIVE MATERIALS
Volume5Issue:4Pages:1127-1137
AbstractAstronauts are under high stress for a long time because of the microgravity condition, which leads to anxiety, affects their learning and memory abilities, and seriously impairs the health of astronauts. Aromatherapy can improve the physical and mental health of astronauts in a way that moisturizes them softly and silently. However, the strong volatility of fragrances and inconvenience of aroma treatment greatly limit their application in the field of spaceflight. In this study, reactive mesoporous silica nanoparticles were prepared to encapsulate and slowly release limonene. The limonene loaded nanoparticles were named limonene@mesoporous silica nanoparticles-cyanuric chloride (LE@MSNs-CYC). LE@MSNs-CYC were then applied to wallpaper to improve the convenience of aromatherapy. LE@MSNs-CYC could chemically react with the wallpaper, thus firmly adsorbed on the wallpaper. In the following, the mice were treated with hindlimb unloading (HU) to simulate a microgravity environment. The results showed that 28-day HU led to an increase in the level of anxiety and declines in learning, memory, and physical health in mice. LE@MSNs-CYC showed significant relief effects on anxiety, learning, memory, and physical health of HU treated mice. Subsequently, the molecular mechanisms were explored by hypothalamic-pituitary-adrenal axis related hormones, immune-related cytokines, learning, and memory-related neurotransmitters and proteins.
KeywordReactive mesoporous silica nanoparticles Slow release of limonene Simulated microgravity condition Improvement of physical health Improvement of mental health
DOI10.1016/j.bioactmat.2020.07.006
Language英语
WOS KeywordELEVATED PLUS-MAZE ; HPA-AXIS ; STRESS-RESPONSE ; SPATIAL MEMORY ; ESSENTIAL OILS ; ANXIETY ; FRAGRANCE ; CARRIERS ; PRODRUG ; SYSTEM
Funding ProjectNational High Technology Research and Development Program[2016YFA0200303] ; Beijing Natural Science Foundation[L172046,2192057] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[21905283]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
Funding OrganizationNational High Technology Research and Development Program ; Beijing Natural Science Foundation ; National Natural Science Foundation of China
WOS IDWOS:000562478100033
PublisherKEAI PUBLISHING LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41775
Collection中国科学院过程工程研究所
Corresponding AuthorLi, Yinghui; Zhang, Xin
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.China Astronaut Res & Training Ctr, State Key Lab Space Med Fundamentals & Applicat, Beijing 100094, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
4.Shanghai Res Inst Fragrance & Flavor Ind, Shanghai 200232, Peoples R China
5.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 200233, Peoples R China
Recommended Citation
GB/T 7714
Lu, Zhiguo,Wang, Jianze,Qu, Lina,et al. Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition[J]. BIOACTIVE MATERIALS,2020,5(4):1127-1137.
APA Lu, Zhiguo.,Wang, Jianze.,Qu, Lina.,Kan, Guanghan.,Zhang, Tianlu.,...&Zhang, Xin.(2020).Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition.BIOACTIVE MATERIALS,5(4),1127-1137.
MLA Lu, Zhiguo,et al."Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition".BIOACTIVE MATERIALS 5.4(2020):1127-1137.
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