CAS OpenIR
Engineering magnetosomes with chimeric membrane and hyaluronidase for efficient delivery of HIF-1 siRNA into deep hypoxic tumors
Lyu, Chengliang1,2; Lu, Guihong1; Bao, Weier1,3; Li, Feng1,3; Wang, Shuang1; Zhang, Fan1; Gao, Xiaoyong1; Kamiya, Hidehiro2; Ma, Guanghui1,3; Wei, Wei1,3
2020-10-15
Source PublicationCHEMICAL ENGINEERING JOURNAL
ISSN1385-8947
Volume398Pages:12
AbstractHypoxia-inducible factor-1 (HIF-1) plays a critical role in tumor development and chemotherapy resistance, and suppression of HIF-1 has emerged as a captivating antitumor approach. To efficiently silence HIF-1 in deep hypoxic tumors, we herein developed a versatile small interfering RNA delivery system that could overcome multiple physiological barriers. The system is comprised of an Fe3O4 magnetic nanocluster as the core, pre-engineered chimeric membrane for the cloak, and decorated hyaluronidase on the surface, which succeeded in prolonged circulation time, magnetic resonance imaging guidance, magnetic tumor accumulation, hypoxic site penetration, homotypic tumor targeting, and cytoplasmic trafficking. Such versatile and programmed delivery performance enabled the engineered magnetosomes to achieve the remarkable silencing of HIF-1, potent therapeutic effect and chemoresistance amelioration with few abnormalities, showing a promising modality for anticancer therapy.
KeywordTumor-macrophage chimeric cell membrane Hyaluronidase Small interfering RNA delivery Hypoxia Hypoxia-inducible factor-1
DOI10.1016/j.cej.2020.125453
Language英语
WOS KeywordCELL ; THERAPY
Funding ProjectNational Natural Science Foundation of China[21622608] ; National Natural Science Foundation of China[21821005] ; National Key R&D Program of China[2017YFA0207900]
WOS Research AreaEngineering
WOS SubjectEngineering, Environmental ; Engineering, Chemical
Funding OrganizationNational Natural Science Foundation of China ; National Key R&D Program of China
WOS IDWOS:000561583200009
PublisherELSEVIER SCIENCE SA
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41778
Collection中国科学院过程工程研究所
Corresponding AuthorWei, Wei
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China
2.Tokyo Univ Agr & Technol, Grad Sch Bioapplicat & Syst Engn, 2-24-16 Naka Cho, Koganei, Tokyo 1848588, Japan
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Lyu, Chengliang,Lu, Guihong,Bao, Weier,et al. Engineering magnetosomes with chimeric membrane and hyaluronidase for efficient delivery of HIF-1 siRNA into deep hypoxic tumors[J]. CHEMICAL ENGINEERING JOURNAL,2020,398:12.
APA Lyu, Chengliang.,Lu, Guihong.,Bao, Weier.,Li, Feng.,Wang, Shuang.,...&Wei, Wei.(2020).Engineering magnetosomes with chimeric membrane and hyaluronidase for efficient delivery of HIF-1 siRNA into deep hypoxic tumors.CHEMICAL ENGINEERING JOURNAL,398,12.
MLA Lyu, Chengliang,et al."Engineering magnetosomes with chimeric membrane and hyaluronidase for efficient delivery of HIF-1 siRNA into deep hypoxic tumors".CHEMICAL ENGINEERING JOURNAL 398(2020):12.
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