CAS OpenIR
Human Motion Driven Self-Powered Photodynamic System for Long-Term Autonomous Cancer Therapy
Liu, Zhuo1,3; Xu, Lingling3,4; Zheng, Qiang3,4; Kang, Yong4,6; Shi, Bojing1,3; Jiang, Dongjie3,4; Li, Hu1,3; Qu, Xuecheng3,4; Fan, Yubo1,2; Wang, Zhong Lin3,4,5; Li, Zhou3,4
2020-07-28
Source PublicationACS NANO
ISSN1936-0851
Volume14Issue:7Pages:8074-8083
AbstractLong-term and low-dose photodynamic therapy for treating tumors requires a sustainable energy supply. The power source technology of batteries and wireless charging for driving a light-emitting diode (LED) may cause inconveniences during treatment. In addition, the development of telemedicine and Internet medicine put forward higher demands on treatment methods, such as better patient compliance and autonomous management. Here, we show a self-powered photodynamic therapy (s-PDT) system with two different irradiation modes that can be autonomously managed by or death patients. The as-fabricated s-PDT system based on a twinning structured piezoelectric nanogenerator is powered by energy harvested from body motion and realizes effective tumor tissue killing and inhibition. As demonstrated at the cellular level, the s-PDT system can significantly suppress tumor cell growth with the pulsed light stimulation mode. When the miniature LED was implanted subcutaneously in mice with transplanted tumors, the s-PDT system led to significant antitumor effects by irradiation with intermittent continuous light stimulation mode for 12 days, and an 87.46% tumor inhibition rate was obtained. This innovative s-PDT system combined with two treatment modes may provide a great opportunity to develop wearable/implantable and self-controllable devices for long-term photodynamic therapy, which would be a promising method for clinical cancer treatment.
Keywordhuman motion self-powered device photodynamic therapy cancer therapy wearable
DOI10.1021/acsnano.0c00675
Language英语
WOS KeywordLIGHT DELIVERY ; PHOTOSENSITIZER ; TUMOR ; PROLIFERATION ; PACEMAKER
Funding ProjectNational Key R&D project from Minister of Science and Technology, China[2016YFA0202703] ; National Natural Science Foundation of China[61875015] ; National Natural Science Foundation of China[81601629] ; National Natural Science Foundation of China[21801019] ; National Natural Science Foundation of China[11421202] ; National Natural Science Foundation of China[11827803] ; 111 Project[B13003] ; Beijing Natural Science Foundation[7204333] ; Key-Area Research and Development Program of Guangdong Province[2018B030331001] ; University of Chinese Academy of Sciences[Y954019] ; National Youth Talent Support Program
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Key R&D project from Minister of Science and Technology, China ; National Natural Science Foundation of China ; 111 Project ; Beijing Natural Science Foundation ; Key-Area Research and Development Program of Guangdong Province ; University of Chinese Academy of Sciences ; National Youth Talent Support Program
WOS IDWOS:000557762800033
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41797
Collection中国科学院过程工程研究所
Corresponding AuthorFan, Yubo; Wang, Zhong Lin; Li, Zhou
Affiliation1.Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Key Lab Biomech & Mechanobiol, Minist Educ,Sch Biol Sci & Med Engn, Beijing 100083, Peoples R China
2.Natl Res Ctr Rehabil Tech Aids, Beijing 100176, Peoples R China
3.Chinese Acad Sci, CAS Ctr Excellence Nanosci, Beijing Key Lab Micronano Energy & Sensor, Beijing Inst Nanoenergy & Nanosyst, Beijing 100083, Peoples R China
4.Univ Chinese Acad Sci, Sch Nanosci & Technol, Beijing 100049, Peoples R China
5.Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA
6.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Liu, Zhuo,Xu, Lingling,Zheng, Qiang,et al. Human Motion Driven Self-Powered Photodynamic System for Long-Term Autonomous Cancer Therapy[J]. ACS NANO,2020,14(7):8074-8083.
APA Liu, Zhuo.,Xu, Lingling.,Zheng, Qiang.,Kang, Yong.,Shi, Bojing.,...&Li, Zhou.(2020).Human Motion Driven Self-Powered Photodynamic System for Long-Term Autonomous Cancer Therapy.ACS NANO,14(7),8074-8083.
MLA Liu, Zhuo,et al."Human Motion Driven Self-Powered Photodynamic System for Long-Term Autonomous Cancer Therapy".ACS NANO 14.7(2020):8074-8083.
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