CAS OpenIR
Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly
Li, Shukun1,3; Zhang, Wenjia2; Xue, Huadan2; Xing, Ruirui1; Yan, Xuehai1,3
2020-09-07
Source PublicationCHEMICAL SCIENCE
ISSN2041-6520
Volume11Issue:33Pages:8644-8656
AbstractThe aberrant metabolism of tumor cells creates an inimitable microenvironment featuring acidic pH, high glutathione (GSH) levels, and overexpression of certain enzymes, which benefits the overwhelming progress of a tumor. Peptide self-assembly, emerging as a biofriendly and versatile fabrication strategy, harnesses multiple noncovalent interactions to obtain a variety of nanostructures tailored on demand. Orchestrating the reversible nature of noncovalent interactions and abnormal physiological parameters in the tumor microenvironment enables peptide-based nanodrugs to be targetable or switchable, thereby improving the drugs' bioavailability and optimizing the treatment outcome. This review will focus on peptide-modulated self-assembly of photosensitizers, chemotherapeutic drugs, immunoactive agents for tumor microenvironment-oriented adaptive phototherapy, chemotherapy, immunotherapy and combinatorial therapy. We will emphasize the building block design, the intermolecular interaction principle, adaptive structural transformation in the tumor microenvironment and corresponding therapeutic efficacy, and aim to elucidate the critical role of peptide-modulated, tumor microenvironment-oriented adaptive assemblies in improving the therapeutic index. Challenges and opportunities will be covered as well to advance the development and clinical application of tumor therapies based on peptide self-assembly materials and techniques.
DOI10.1039/d0sc02937h
Language英语
WOS KeywordPHOTODYNAMIC THERAPY ; SUPRAMOLECULAR HYDROGELS ; EMERGING APPLICATIONS ; BETA-SHEET ; PH ; DELIVERY ; NANOPARTICLES ; CONJUGATE ; VACCINE ; NANOMATERIALS
Funding ProjectNational Natural Science Foundation of China[21802144] ; National Natural Science Fund BRICS STI Framework Program[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Program ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)
WOS IDWOS:000562597500001
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41842
Collection中国科学院过程工程研究所
Corresponding AuthorXue, Huadan; Xing, Ruirui; Yan, Xuehai
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Peking Union Med Coll Hosp, Dept Radiol, Beijing 100730, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Shukun,Zhang, Wenjia,Xue, Huadan,et al. Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly[J]. CHEMICAL SCIENCE,2020,11(33):8644-8656.
APA Li, Shukun,Zhang, Wenjia,Xue, Huadan,Xing, Ruirui,&Yan, Xuehai.(2020).Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly.CHEMICAL SCIENCE,11(33),8644-8656.
MLA Li, Shukun,et al."Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly".CHEMICAL SCIENCE 11.33(2020):8644-8656.
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