CAS OpenIR
Exosome: a significant nano-scale drug delivery carrier
Peng, Huan1,2; Ji, Weihong1,2; Zhao, Ruichen1,2; Yang, Jun1,2; Lu, Zhiguo1,2; Li, Yan1,2; Zhang, Xin1,2
2020-09-14
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume8Issue:34Pages:7591-7608
AbstractIn recent years, due to the limitations of the nature of therapeutic agents, many synthetic nano-delivery systems have emerged to enhance the efficacy of drugs. Extracellular vesicles are currently a class of natural nano-scale drug carriers released by cells. As a tiny vesicle with a lipid bilayer membrane that can be secreted by most cells in the body, exosomes carry and transmit important signal molecules, Therefore, they have been a research hotspot in biomedicine and biomaterials due to their size advantages and huge potential in drug therapy. Many people are optimistic about the clinical application prospects of exosomes and are actively exploring the broad functions of exosomes and developing exosome therapeutic agents to make positive contributions to human health. In this review, we provide basic knowledge and focus on summarizing the advantages of exosomes as drug carriers, methods of loading drugs, targeting strategies,in vivoandin vitrotracing methods, and some of the latest developments in exosomes as drug carriers. In particular, the review provides an outlook for this field.
DOI10.1039/d0tb01499k
Language英语
WOS KeywordCELL-DERIVED EXOSOMES ; DENSITY-GRADIENT SEPARATION ; STRANDED GENOMIC DNA ; EXTRACELLULAR VESICLES ; IN-VIVO ; MESSENGER-RNA ; INTERCELLULAR COMMUNICATION ; ANTIGEN PRESENTATION ; MEDIATED DELIVERY ; STROMAL CELLS
Funding ProjectBeijing Natural Science Foundation[2192057] ; Beijing Natural Science Foundation[L172046] ; National High Technology Research and Development Program[2016YFA0200303] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[21905283]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
Funding OrganizationBeijing Natural Science Foundation ; National High Technology Research and Development Program ; National Natural Science Foundation of China
WOS IDWOS:000565996500002
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41879
Collection中国科学院过程工程研究所
Corresponding AuthorLi, Yan; Zhang, Xin
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Peng, Huan,Ji, Weihong,Zhao, Ruichen,et al. Exosome: a significant nano-scale drug delivery carrier[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(34):7591-7608.
APA Peng, Huan.,Ji, Weihong.,Zhao, Ruichen.,Yang, Jun.,Lu, Zhiguo.,...&Zhang, Xin.(2020).Exosome: a significant nano-scale drug delivery carrier.JOURNAL OF MATERIALS CHEMISTRY B,8(34),7591-7608.
MLA Peng, Huan,et al."Exosome: a significant nano-scale drug delivery carrier".JOURNAL OF MATERIALS CHEMISTRY B 8.34(2020):7591-7608.
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