CAS OpenIR
Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy
Wang, Jianghua1,2; Wang, Shuang1; Ye, Tong1,2; Li, Feng1,2; Gao, Xiaoyong1; Wang, Yan1,2; Ye, Peng1; Qing, Shuang1,2; Wang, Changlong1,2; Yue, Hua1; Wu, Jie1; Wei, Wei1,2; Ma, Guanghui1,2
2020-08-15
Source PublicationADVANCED SCIENCE
Pages17
AbstractNanovaccines have attracted booming interests in vaccinology studies, but the profound impacts of their delivery mode on immune response remain unrealized. Herein, immunostimulatory CpG-modified tumor-derived nanovesicles (CNVs) are used as a nanovaccine testbed to initially evaluate the impacts of three distinct delivery modes, including mono-pulse CNVs, staggered-pulse CNVs, and gel-confined CNVs. Fundamentally, delivery mode has enormous impacts on the immunomodulatory effects, altering the spatiotemporal distribution of nanovaccine residence and dendritic cell-T cell interaction in lymph nodes, and finally affecting subsequent T cell-mediated immune performance. As a result, the gel-confined delivery mode offers the best therapeutic performance in multiple tumor models. When extending evaluation to examine how the various delivery modes impact the performance of liposome-based nanovaccines, similar trends in intralymph node distribution and antitumor effect are observed. This work provides a strong empirical foundation that nanovaccine researchers should position delivery mode near the top of their considerations for the experimental design, which should speed up nanovaccine development and facilitate efficient selection of appropriate delivery modes in the clinic.
Keyworddelivery modes hydrogels lymph nodes nanovaccines tumor immunotherapy
DOI10.1002/advs.202001108
Language英语
WOS KeywordCELLS IN-VIVO ; DENDRITIC CELLS ; LYMPH-NODE ; QUATERNIZED CHITOSAN ; VACCINE DELIVERY ; HYDROGEL ; NANOPARTICLES ; ENCAPSULATION ; BIOMATERIALS ; ANTIGENS
Funding ProjectInnovative Research Group Project of the National Natural Science Foundation of China[21821005] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] ; National Key Research and Development Program of China[2017YFA0207900] ; Beijing Municipal Natural Science Foundation[2202056]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationInnovative Research Group Project of the National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Key Research and Development Program of China ; Beijing Municipal Natural Science Foundation
WOS IDWOS:000565309100001
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41903
Collection中国科学院过程工程研究所
Corresponding AuthorWei, Wei; Ma, Guanghui
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jianghua,Wang, Shuang,Ye, Tong,et al. Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy[J]. ADVANCED SCIENCE,2020:17.
APA Wang, Jianghua.,Wang, Shuang.,Ye, Tong.,Li, Feng.,Gao, Xiaoyong.,...&Ma, Guanghui.(2020).Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy.ADVANCED SCIENCE,17.
MLA Wang, Jianghua,et al."Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy".ADVANCED SCIENCE (2020):17.
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