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| Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection | |
Wu, Yanyue1,2; Lu, Zhiguo1,2; Li, Yan1 ; Yang, Jun1,2; Zhang, Xin1,2
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| 2020-08-01 | |
| Source Publication | NANOMATERIALS
 |
| Volume | 10Issue:8Pages:21 |
| Abstract | Combining diagnosis with therapy, magnetic iron oxide nanoparticles (INOPs) act as an important vehicle for drug delivery. However, poor biocompatibility of INOPs limits their application. To improve the shortcomings, various surface modifications have been developed, including small molecules coatings, polymers coatings, lipid coatings and lipopolymer coatings. These surface modifications facilitate iron nanoparticles to cross the blood-brain-barrier, which is essential for diagnosis and treatments of brain diseases. Here we focus on the characteristics of different coated INOPs and their application in brain disease, particularly gliomas, Alzheimer's disease (AD) and Parkinson's disease (PD). Moreover, we summarize the current progress and expect to provide help for future researches. |
| Keyword | theranostics iron oxide magnetic nanoparticles blood-brain barrier surface coating target therapy |
| DOI | 10.3390/nano10081441 |
| Language | 英语 |
| WOS Keyword | ALZHEIMERS-DISEASE ; DRUG-DELIVERY ; IMAGING PROBE ; CANCER ; ACID ; MRI ; DESIGN ; PERMEABILITY ; STRATEGIES ; CHITOSAN |
| Funding Project | National High-tech Research and Development Program[2016YFA0200303] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[21905283] ; Natural Science Foundation of Beijing Municipality[L172046] ; Natural Science Foundation of Beijing Municipality[2192057] |
| WOS Research Area | Science & Technology - Other Topics ; Materials Science |
| WOS Subject | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| Funding Organization | National High-tech Research and Development Program ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality |
| WOS ID | WOS:000567363900001 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/41946 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Yang, Jun; Zhang, Xin |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Wu, Yanyue,Lu, Zhiguo,Li, Yan,et al. Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection[J]. NANOMATERIALS,2020,10(8):21. |
| APA | Wu, Yanyue,Lu, Zhiguo,Li, Yan,Yang, Jun,&Zhang, Xin.(2020).Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection.NANOMATERIALS,10(8),21. |
| MLA | Wu, Yanyue,et al."Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection".NANOMATERIALS 10.8(2020):21. |
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