CAS OpenIR
Particulate Alum via Pickering Emulsion for an Enhanced COVID-19 Vaccine Adjuvant
Peng, Sha1,2; Cao, Fengqiang1,3; Xia, Yufei1,4,5; Gao, Xiao-Dong2; Dai, Lianpan6; Yan, Jinghua7; Ma, Guanghui1,4,5
2020-08-30
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Pages7
AbstractFor rapid response against the prevailing COVID-19 (coronavirus disease 19), it is a global imperative to exploit the immunogenicity of existing formulations for safe and efficient vaccines. As the most accessible adjuvant, aluminum hydroxide (alum) is still the sole employed adjuvant in most countries. However, alum tends to attach on the membrane rather than entering the dendritic cells (DCs), leading to the absence of intracellular transfer and process of the antigens, and thus limits T-cell-mediated immunity. To address this, alum is packed on the squalene/water interphase is packed, forming an alum-stabilized Pickering emulsion (PAPE). "Inheriting" from alum and squalene, PAPE demonstrates a good biosafety profile. Intriguingly, with the dense array of alum on the oil/water interphase, PAPE not only adsorbs large quantities of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) antigens, but also harbors a higher affinity for DC uptake, which provokes the uptake and cross-presentation of the delivered antigens. Compared with alum-treated groups, more than six times higher antigen-specific antibody titer and three-fold more IFN-gamma-secreting T cells are induced, indicating the potent humoral and cellular immune activations. Collectively, the data suggest that PAPE may provide potential insights toward a safe and efficient adjuvant platform for the enhanced COVID-19 vaccinations.
Keywordalum cellular immune responses COVID-19 vaccine adjuvant Pickering emulsion SARS-CoV-2
DOI10.1002/adma.202004210
Language英语
WOS KeywordT-CELLS ; CLEARANCE ; MICROGELS ; DESIGN ; VIRUS ; MERS
Funding ProjectFoundation for Innovative Research Groups of the National Natural Science Foundation of China[21821005] ; Pilot Project of Chinese Academy of Sciences[XDB29040303] ; Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences[2020000071] ; Youth Project of National Natural Science Foundation of China[21908229] ; National Natural Science Foundation of China[21776287] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2020000053] ; Key External Cooperation Program of Chinese Academy of Sciences[122111KYSB20180021]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationFoundation for Innovative Research Groups of the National Natural Science Foundation of China ; Pilot Project of Chinese Academy of Sciences ; Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences ; Youth Project of National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Key External Cooperation Program of Chinese Academy of Sciences
WOS IDWOS:000564582700001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41970
Collection中国科学院过程工程研究所
Corresponding AuthorXia, Yufei; Ma, Guanghui
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Wuxi 214122, Jiangsu, Peoples R China
3.Tokyo Univ Agr & Technol, Grad Sch Bioapplicat & Syst Engn, 2-24-16 Nakacho, Koganei, Tokyo 1848588, Japan
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Innovat Acad Green Manufacture, Beijing 100190, Peoples R China
6.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China
7.Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Peng, Sha,Cao, Fengqiang,Xia, Yufei,et al. Particulate Alum via Pickering Emulsion for an Enhanced COVID-19 Vaccine Adjuvant[J]. ADVANCED MATERIALS,2020:7.
APA Peng, Sha.,Cao, Fengqiang.,Xia, Yufei.,Gao, Xiao-Dong.,Dai, Lianpan.,...&Ma, Guanghui.(2020).Particulate Alum via Pickering Emulsion for an Enhanced COVID-19 Vaccine Adjuvant.ADVANCED MATERIALS,7.
MLA Peng, Sha,et al."Particulate Alum via Pickering Emulsion for an Enhanced COVID-19 Vaccine Adjuvant".ADVANCED MATERIALS (2020):7.
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