Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease

doi:10.1186/s12951-020-00723-1

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	Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease
	Liu,Xiao-ge 1,2; Zhang,Lun 1,2; Lu,Shuai 1; Liu,Dong-qun 1; Huang,Ya-ru 1,2; Zhu,Jie 1; Zhou,Wei-wei 1; Yu,Xiao-lin 1; Liu,Rui-tian 1
	2020-11-07
Source Publication	Journal of Nanobiotechnology
Volume	18 Issue:1
Abstract	AbstractBackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder. No disease-modifying strategy to prevent or delay AD progression currently exists. Aβ oligomers (AβOs), rather than monomers or fibrils, are considered as the primary neurotoxic species. Therapeutic approaches that direct against AβOs and promote Aβ clearance may have great value for AD treatment.ResultsWe here reported a multifunctional superparamagnetic iron oxide nanoparticle conjugated with Aβ?oligomer-specific scFv antibody W20 and class A scavenger receptor activator XD4 (W20/XD4-SPIONs). Besides the diagnostic value, W20/XD4-SPIONs retained the anti-Aβ properties of W20 and XD4 by inhibiting Aβ aggregation, attenuating AβO-induced cytotoxicity and increasing microglial phagocytosis of Aβ. When applied to APP/PS1 mice, W20/XD4-SPIONs significantly rescued cognitive deficits and alleviated neuropathology of AD mice.ConclusionThese results suggest that W20/XD4-SPIONs show therapeutic benefits for AD. In combination with the early diagnostic property, W20/XD4-SPIONs present as a promising agent for early-stage AD diagnosis and intervention.
Keyword	Alzheimer’s disease β-Amyloid Oligomer Class A scavenger receptor Therapy
DOI	10.1186/s12951-020-00723-1
Language	英语
WOS ID	BMC:10.1186/s12951-020-00723-1
Publisher	BioMed Central
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Document Type	期刊论文
Identifier	http://ir.ipe.ac.cn/handle/122111/41976
Collection	中国科学院过程工程研究所
Corresponding Author	Yu,Xiao-lin; Liu,Rui-tian
Affiliation	1.Chinese Academy of Sciences; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering 2.University of Chinese Academy of Sciences; School of Chemical Engineering
Recommended Citation GB/T 7714	Liu,Xiao-ge,Zhang,Lun,Lu,Shuai,等. Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease[J]. Journal of Nanobiotechnology,2020,18(1).
APA	Liu,Xiao-ge.,Zhang,Lun.,Lu,Shuai.,Liu,Dong-qun.,Huang,Ya-ru.,...&Liu,Rui-tian.(2020).Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease.Journal of Nanobiotechnology,18(1).
MLA	Liu,Xiao-ge,et al."Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease".Journal of Nanobiotechnology 18.1(2020).

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