CAS OpenIR
Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease
Liu,Xiao-ge1,2; Zhang,Lun1,2; Lu,Shuai1; Liu,Dong-qun1; Huang,Ya-ru1,2; Zhu,Jie1; Zhou,Wei-wei1; Yu,Xiao-lin1; Liu,Rui-tian1
2020-11-07
Source PublicationJournal of Nanobiotechnology
Volume18Issue:1
AbstractAbstractBackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder. No disease-modifying strategy to prevent or delay AD progression currently exists. Aβ oligomers (AβOs), rather than monomers or fibrils, are considered as the primary neurotoxic species. Therapeutic approaches that direct against AβOs and promote Aβ clearance may have great value for AD treatment.ResultsWe here reported a multifunctional superparamagnetic iron oxide nanoparticle conjugated with Aβ?oligomer-specific scFv antibody W20 and class A scavenger receptor activator XD4 (W20/XD4-SPIONs). Besides the diagnostic value, W20/XD4-SPIONs retained the anti-Aβ properties of W20 and XD4 by inhibiting Aβ aggregation, attenuating AβO-induced cytotoxicity and increasing microglial phagocytosis of Aβ. When applied to APP/PS1 mice, W20/XD4-SPIONs significantly rescued cognitive deficits and alleviated neuropathology of AD mice.ConclusionThese results suggest that W20/XD4-SPIONs show therapeutic benefits for AD. In combination with the early diagnostic property, W20/XD4-SPIONs present as a promising agent for early-stage AD diagnosis and intervention.
KeywordAlzheimer’s disease β-Amyloid Oligomer Class A scavenger receptor Therapy
DOI10.1186/s12951-020-00723-1
Language英语
WOS IDBMC:10.1186/s12951-020-00723-1
PublisherBioMed Central
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/41976
Collection中国科学院过程工程研究所
Corresponding AuthorYu,Xiao-lin; Liu,Rui-tian
Affiliation1.Chinese Academy of Sciences; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering
2.University of Chinese Academy of Sciences; School of Chemical Engineering
Recommended Citation
GB/T 7714
Liu,Xiao-ge,Zhang,Lun,Lu,Shuai,等. Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease[J]. Journal of Nanobiotechnology,2020,18(1).
APA Liu,Xiao-ge.,Zhang,Lun.,Lu,Shuai.,Liu,Dong-qun.,Huang,Ya-ru.,...&Liu,Rui-tian.(2020).Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease.Journal of Nanobiotechnology,18(1).
MLA Liu,Xiao-ge,et al."Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease".Journal of Nanobiotechnology 18.1(2020).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Liu,Xiao-ge]'s Articles
[Zhang,Lun]'s Articles
[Lu,Shuai]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liu,Xiao-ge]'s Articles
[Zhang,Lun]'s Articles
[Lu,Shuai]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liu,Xiao-ge]'s Articles
[Zhang,Lun]'s Articles
[Lu,Shuai]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.