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Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy
Zhang, Fan1,2; Lu, Guihong3; Wen, Xiaolei2; Li, Feng3; Ji, Xiaoyuan1; Li, Qianqian1; Wu, Meiying1; Cheng, Qinzhen1; Yu, Yongkang1; Tang, Jing1; Mei, Lin1,4
2020-10-10
Source PublicationJOURNAL OF CONTROLLED RELEASE
ISSN0168-3659
Volume326Pages:131-139
AbstractAs the combination of photothermal therapy (PTT) with immunotherapy provides an effective strategy in cancer treatment, a magnetic nanoparticle delivery system was constructed to load indocyanine green (ICG) and immunostimulator R837 hydrochloride (R837) for spatio-temporally PTT/immunotherapy synergism in cancer. This delivery system is composed of Fe3O4 magnetic nanoparticles (MPs) as the core to load ICG and polyethylene glycol polyphenols (DPA-PEG) as the coating layer to load R837, which formed R837 loaded polyphenols coating ICG loaded magnetic nanoparticles (MIRDs). After intravenous injection, the formed MIRDs resulted in long circulation, magnetic resonance imaging (MRI) guides, and magnetic targeting. Once targeting to the tumor, the MIRDs with the near-infrared (NIR) irradiation caused tumor ablation and resulted in tumor-associated antigens releasing to induce the body's immunological response, which was markedly improved it to attack the tumors with the R837 releasing from the outer DPA-PEG. In this case, the synergism of the PTT and immunotherapy inhibited tumor growth, metastasis and recurrence, which resulted in potent anticancer therapeutic effects with few side effect.
KeywordMagnetic nanoparticles Photothermal therapy Immunotherapy Synergism Cancer
DOI10.1016/j.jconrel.2020.06.015
Language英语
WOS KeywordPHOTODYNAMIC THERAPY ; CHECKPOINT BLOCKADE ; PHOTOTHERMAL THERAPY ; IMMUNITY
Funding ProjectNational Natural Science Foundation of China[31922042] ; National Natural Science Foundation of China[31800842] ; National Natural Science Foundation of China[81771966] ; National Natural Science Foundation of China[81801843] ; National Natural Science Foundation of China[81971737] ; Fundamental Research Funds for the Central Universities[31610008] ; Fundamental Research Funds for the Central Universities[2019PT320028] ; Program for the Top-notch Young Talents of Hebei Province[BJ2016025]
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
Funding OrganizationNational Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Program for the Top-notch Young Talents of Hebei Province
WOS IDWOS:000572083700003
PublisherELSEVIER
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/42194
Collection中国科学院过程工程研究所
Corresponding AuthorMei, Lin
Affiliation1.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen 518107, Peoples R China
2.Hebei Normal Univ Sci & Technol, Hebei Key Lab Act Components & Funct Nat Prod, Qinhuangdao 066004, Hebei, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Chinese Acad Med Sci & Peking Union Med Coll, Inst Biomed Engn, Tianjin Key Lab Biomed Mat, Key Lab Biomat & Nanotechnol Canc Immunotherapy, Tianjin 300192, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Fan,Lu, Guihong,Wen, Xiaolei,et al. Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy[J]. JOURNAL OF CONTROLLED RELEASE,2020,326:131-139.
APA Zhang, Fan.,Lu, Guihong.,Wen, Xiaolei.,Li, Feng.,Ji, Xiaoyuan.,...&Mei, Lin.(2020).Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy.JOURNAL OF CONTROLLED RELEASE,326,131-139.
MLA Zhang, Fan,et al."Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy".JOURNAL OF CONTROLLED RELEASE 326(2020):131-139.
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