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| Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy | |
| Zhang, Fan1,2; Lu, Guihong3; Wen, Xiaolei2; Li, Feng3; Ji, Xiaoyuan1; Li, Qianqian1; Wu, Meiying1; Cheng, Qinzhen1; Yu, Yongkang1; Tang, Jing1; Mei, Lin1,4 | |
| 2020-10-10 | |
| Source Publication | JOURNAL OF CONTROLLED RELEASE
 |
| ISSN | 0168-3659 |
| Volume | 326Pages:131-139 |
| Abstract | As the combination of photothermal therapy (PTT) with immunotherapy provides an effective strategy in cancer treatment, a magnetic nanoparticle delivery system was constructed to load indocyanine green (ICG) and immunostimulator R837 hydrochloride (R837) for spatio-temporally PTT/immunotherapy synergism in cancer. This delivery system is composed of Fe3O4 magnetic nanoparticles (MPs) as the core to load ICG and polyethylene glycol polyphenols (DPA-PEG) as the coating layer to load R837, which formed R837 loaded polyphenols coating ICG loaded magnetic nanoparticles (MIRDs). After intravenous injection, the formed MIRDs resulted in long circulation, magnetic resonance imaging (MRI) guides, and magnetic targeting. Once targeting to the tumor, the MIRDs with the near-infrared (NIR) irradiation caused tumor ablation and resulted in tumor-associated antigens releasing to induce the body's immunological response, which was markedly improved it to attack the tumors with the R837 releasing from the outer DPA-PEG. In this case, the synergism of the PTT and immunotherapy inhibited tumor growth, metastasis and recurrence, which resulted in potent anticancer therapeutic effects with few side effect. |
| Keyword | Magnetic nanoparticles Photothermal therapy Immunotherapy Synergism Cancer |
| DOI | 10.1016/j.jconrel.2020.06.015 |
| Language | 英语 |
| WOS Keyword | PHOTODYNAMIC THERAPY ; CHECKPOINT BLOCKADE ; PHOTOTHERMAL THERAPY ; IMMUNITY |
| Funding Project | National Natural Science Foundation of China[31922042] ; National Natural Science Foundation of China[31800842] ; National Natural Science Foundation of China[81771966] ; National Natural Science Foundation of China[81801843] ; National Natural Science Foundation of China[81971737] ; Fundamental Research Funds for the Central Universities[31610008] ; Fundamental Research Funds for the Central Universities[2019PT320028] ; Program for the Top-notch Young Talents of Hebei Province[BJ2016025] |
| WOS Research Area | Chemistry ; Pharmacology & Pharmacy |
| WOS Subject | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| Funding Organization | National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Program for the Top-notch Young Talents of Hebei Province |
| WOS ID | WOS:000572083700003 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/42194 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Mei, Lin |
| Affiliation | 1.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen 518107, Peoples R China 2.Hebei Normal Univ Sci & Technol, Hebei Key Lab Act Components & Funct Nat Prod, Qinhuangdao 066004, Hebei, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Chinese Acad Med Sci & Peking Union Med Coll, Inst Biomed Engn, Tianjin Key Lab Biomed Mat, Key Lab Biomat & Nanotechnol Canc Immunotherapy, Tianjin 300192, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Fan,Lu, Guihong,Wen, Xiaolei,et al. Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy[J]. JOURNAL OF CONTROLLED RELEASE,2020,326:131-139. |
| APA | Zhang, Fan.,Lu, Guihong.,Wen, Xiaolei.,Li, Feng.,Ji, Xiaoyuan.,...&Mei, Lin.(2020).Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy.JOURNAL OF CONTROLLED RELEASE,326,131-139. |
| MLA | Zhang, Fan,et al."Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy".JOURNAL OF CONTROLLED RELEASE 326(2020):131-139. |
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