CAS OpenIR
Injectable ferrimagnetic silk fibroin hydrogel for magnetic hyperthermia ablation of deep tumor
Qian, Kun-Yu1; Song, Yonghong1; Yan, Xu1; Dong, Liang2; Xue, Jingzhe1; Xu, Yunjun3; Wang, Bao4; Cao, Baoqiang5; Hou, Qingbing5; Peng, Wei5; Hu, Jinlong5; Jiang, Kun1; Chen, Sheng1; Wang, Huiqing1; Lu, Yang1
2020-11-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume259Pages:11
AbstractDue to the well-recognized biocompatibility, silk fibroin hydrogels have been developed for biomedical appli-cations including bone regeneration, drug delivery and cancer therapy. For the treatment of cancer, silk-based photothermal agents exhibit the high photothermal conversion efficiency, but the limited light penetration depth of photothermal therapy restricts the treatment of some tumors in deep positions, such as liver tumor and glioma. To provide an alternative strategy, here we developed an injectable magnetic hydrogel based on silk fibroin and iron oxide nanocubes (IONCs). The as-prepared ferrimagnetic silk fibroin hydrogel could be easily injected through a syringe into tumor, especially rabbit hepatocellular carcinoma in deeper positions using ultrasound-guided interventional treatment. Compared with photothermal agents, the embedded IONCs endowed the ferrimagnetic silk fibroin hydrogel with remote hyperthermia performance under an alternating magnetic field, resulting in the effective magnetic hyperthermia of deep tumors including subcutaneously implanted tumor model in Balb/c mouse after the coverage of a fresh pork tissue and orthotopic transplantation liver tumor in rabbit. Furthermore, due to the confinement of IONCs in silk fibroin hydrogel, the undesired thermal damage toward normal tissue could be avoided compared with directly administrating monodispersed magnetic nanoparticles.
KeywordSilk fibroin Hydrogel Ferrimagnetic Hyperthermia Deep tumor
DOI10.1016/j.biomaterials.2020.120299
Language英语
WOS KeywordIRON-OXIDE NANOCUBES ; IN-VITRO ; NANOPARTICLES ; THERMOTHERAPY ; DELIVERY ; THERAPY ; DESIGN ; MRI
Funding ProjectNational Natural Science Foundation of China[51972090] ; National Natural Science Foundation of China[51572067] ; National Natural Science Foundation of China[21501039] ; National Natural Science Foundation of China[21701165] ; National Natural Science Foundation of China[51673074] ; Fundamental Research Funds for the Central Universities[JZ2018HGPA0269] ; Natural Science Foundation of Anhui Province[2008085J06] ; Foundation for State Key Laboratory of Biochemical Engineering[Y624012124] ; China Postdoctoral Science Foundation[2017M612079]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
Funding OrganizationNational Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Natural Science Foundation of Anhui Province ; Foundation for State Key Laboratory of Biochemical Engineering ; China Postdoctoral Science Foundation
WOS IDWOS:000571532400002
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/42206
Collection中国科学院过程工程研究所
Corresponding AuthorXue, Jingzhe; Cao, Baoqiang; Lu, Yang
Affiliation1.Hefei Univ Technol, Key Lab Metab & Regulat Major Dis Anhui Higher Ed, Intelligent Interconnected Syst Lab Anhui Prov, Key Lab Adv Catalyt Mat & React Engn,Sch Chem & C, Hefei 230009, Anhui, Peoples R China
2.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China
3.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Radiol, Div Life Sci & Med, Hefei 230036, Anhui, Peoples R China
4.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
5.Anhui 2 Prov Peoples Hosp, Dept Intervent Radiol, Dept Ultrason, Dept Gen Surg, Hefei 230041, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Qian, Kun-Yu,Song, Yonghong,Yan, Xu,et al. Injectable ferrimagnetic silk fibroin hydrogel for magnetic hyperthermia ablation of deep tumor[J]. BIOMATERIALS,2020,259:11.
APA Qian, Kun-Yu.,Song, Yonghong.,Yan, Xu.,Dong, Liang.,Xue, Jingzhe.,...&Lu, Yang.(2020).Injectable ferrimagnetic silk fibroin hydrogel for magnetic hyperthermia ablation of deep tumor.BIOMATERIALS,259,11.
MLA Qian, Kun-Yu,et al."Injectable ferrimagnetic silk fibroin hydrogel for magnetic hyperthermia ablation of deep tumor".BIOMATERIALS 259(2020):11.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Qian, Kun-Yu]'s Articles
[Song, Yonghong]'s Articles
[Yan, Xu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Qian, Kun-Yu]'s Articles
[Song, Yonghong]'s Articles
[Yan, Xu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Qian, Kun-Yu]'s Articles
[Song, Yonghong]'s Articles
[Yan, Xu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.