CAS OpenIR
Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy
Qing, Shuang1,2; Lyu, Chengliang1; Zhu, Li2,3; Pan, Chao3; Wang, Shuang1; Li, Feng1; Wang, Jianghua1,2; Yue, Hua1; Gao, Xiaoyong1; Jia, Rongrong4; Wei, Wei1,2; Ma, Guanghui1,2
2020-10-05
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Pages14
AbstractThe highly immunosuppressive tumor microenvironment (TME) in solid tumors often dampens the efficacy of immunotherapy. In this study, bacterial outer membrane vesicles (OMVs) are demonstrated as powerful immunostimulants for TME reprogramming. To overcome the obstacles of antibody-dependent clearance and high toxicity induced by OMVs upon intravenous injection (a classic clinically relevant delivery mode), calcium phosphate (CaP) shells are employed to cover the surface of OMVs, which enables potent OMV-based TME reprograming without side effects. Meanwhile, the pH-sensitive CaP shells facilitate the neutralization of acidic TME, leading to highly beneficial M2-to-M1 polarization of macrophages for improved antitumor effect. Moreover, the outer shells can be integrated with functional components like folic acid or photosensitizer agents, which facilitates the use of the OMV-based platform in combination therapies for a synergic therapeutic effect.
Keywordbacterial outer membrane vesicles biomineralization cancer immunotherapy tumor microenvironment reprogramming
DOI10.1002/adma.202002085
Language英语
WOS KeywordT-CELLS ; IMMUNE CELLS ; TGF-BETA ; CANCER ; IMMUNOGENICITY ; IMMUNOTHERAPY ; ANTIBODY ; IMPROVE
Funding ProjectNational Natural Science Foundation of China[21821005] ; National Key R&D Program of China[2017YFA0207900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] ; Regulations for the Care and Use of Laboratory Animals and Guideline for Ethical Review of Animal (China)[GB/T35892-2018]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Natural Science Foundation of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Regulations for the Care and Use of Laboratory Animals and Guideline for Ethical Review of Animal (China)
WOS IDWOS:000574885100001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/42265
Collection中国科学院过程工程研究所
Corresponding AuthorWei, Wei; Ma, Guanghui
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 Bei Er Tiao, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Beijing Inst Biotechnol, State Key Lab Pathogen & Biosecur, 20 Dongda St, Beijing 100071, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Gastroenterol, 1111 Xianxia Rd, Shanghai 200336, Peoples R China
Recommended Citation
GB/T 7714
Qing, Shuang,Lyu, Chengliang,Zhu, Li,et al. Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy[J]. ADVANCED MATERIALS,2020:14.
APA Qing, Shuang.,Lyu, Chengliang.,Zhu, Li.,Pan, Chao.,Wang, Shuang.,...&Ma, Guanghui.(2020).Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy.ADVANCED MATERIALS,14.
MLA Qing, Shuang,et al."Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy".ADVANCED MATERIALS (2020):14.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Qing, Shuang]'s Articles
[Lyu, Chengliang]'s Articles
[Zhu, Li]'s Articles
Baidu academic
Similar articles in Baidu academic
[Qing, Shuang]'s Articles
[Lyu, Chengliang]'s Articles
[Zhu, Li]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Qing, Shuang]'s Articles
[Lyu, Chengliang]'s Articles
[Zhu, Li]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.