CAS OpenIR
Therapeutic vaccination against leukaemia via the sustained release of co-encapsulated anti-PD-1 and a leukaemia-associated antigen
Xie, Xiaoling1,2; Hu, Yuxing1; Ye, Tong2,3; Chen, Yiran1; Zhou, Lijuan1; Li, Feng2,3; Xi, Xiaobo2,3; Wang, Shuang2; He, Yanjie1; Gao, Xiaoyong2; Wei, Wei2,3; Ma, Guanghui2,3; Li, Yuhua1,4
2020-10-12
Source PublicationNATURE BIOMEDICAL ENGINEERING
ISSN2157-846X
Pages19
AbstractThe sustained release of a leukaemia-associated epitope peptide and of anti-PD-1 antibody co-encapsulated in degradable microcapsules results in superior therapeutic outcomes in mouse models of leukaemia. Therapeutic leukaemia vaccines have shown modest potency. Here, we show that the co-encapsulation of a leukaemia-associated epitope peptide highly expressed in leukaemia patients and of the immune checkpoint inhibitor anti-programmed-cell-death-protein-1 (anti-PD-1) in degradable poly(lactic acid) microcapsules resulted in the sustained release of the peptide and of the antibody, which led to the recruitment of activated antigen-presenting cells to the injection site, their uptake of the peptide and the transportation of the anti-PD-1 antibody to lymph nodes, enhancing the expansion of epitope-specific T cells and the activation of cytotoxic T cells. After single subcutaneous injections of vaccine formulations with different epitope peptides, mice bearing leukaemia xenografts derived from humanized cell lines or from primary cells from patients showed better therapeutic outcomes than mice receiving repeated injections of free antigen, antibody and a commercial adjuvant. The sustained release of a tumour-associated peptide and of anti-PD-1 may represent a generalizable strategy for boosting antitumour immune responses to leukaemia.
DOI10.1038/s41551-020-00624-6
Language英语
WOS KeywordACUTE MYELOID-LEUKEMIA ; PEPTIDE VACCINE ; WT1 EXPRESSION ; RESPONSES ; LYMPHOCYTES ; GENERATION ; TRANSPLANTATION ; IMMUNOTHERAPY ; INHIBITION ; BLOCKADE
Funding ProjectNational Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[21622608] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] ; National Key R&D Program of China[2017YFA0207900] ; Science and Technology Program of Guangzhou, China[201704020216] ; Natural Science Foundation of Guangdong Province, China[2018B030311042] ; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, China[2018GZR110105014]
WOS Research AreaEngineering
WOS SubjectEngineering, Biomedical
Funding OrganizationNational Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; Science and Technology Program of Guangzhou, China ; Natural Science Foundation of Guangdong Province, China ; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, China
WOS IDWOS:000577092600001
PublisherNATURE RESEARCH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/42317
Collection中国科学院过程工程研究所
Corresponding AuthorWei, Wei; Ma, Guanghui; Li, Yuhua
Affiliation1.Southern Med Univ, Zhujiang Hosp, Dept Hematol, Guangzhou, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangzhou, Peoples R China
Recommended Citation
GB/T 7714
Xie, Xiaoling,Hu, Yuxing,Ye, Tong,et al. Therapeutic vaccination against leukaemia via the sustained release of co-encapsulated anti-PD-1 and a leukaemia-associated antigen[J]. NATURE BIOMEDICAL ENGINEERING,2020:19.
APA Xie, Xiaoling.,Hu, Yuxing.,Ye, Tong.,Chen, Yiran.,Zhou, Lijuan.,...&Li, Yuhua.(2020).Therapeutic vaccination against leukaemia via the sustained release of co-encapsulated anti-PD-1 and a leukaemia-associated antigen.NATURE BIOMEDICAL ENGINEERING,19.
MLA Xie, Xiaoling,et al."Therapeutic vaccination against leukaemia via the sustained release of co-encapsulated anti-PD-1 and a leukaemia-associated antigen".NATURE BIOMEDICAL ENGINEERING (2020):19.
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