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Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors
Li, Yongxin1; Sun, Pan2; Zhao, Luyang3; Yan, Xuehai3; Ng, Dennis K. P.4; Lo, Pui-Chi1
2020-10-15
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Pages12
AbstractA facile approach to assemble catalase-like photosensitizing nanozymes with a self-oxygen-supplying ability was developed. The process involved Fe3+-driven self-assembly of fluorenylmethyloxycarbonyl (Fmoc)-protected amino acids. By adding a zinc(II) phthalocyanine-based photosensitizer (ZnPc) and the hypoxia-inducible factor 1 (HIF-1) inhibitor acriflavine (ACF) during the Fe3+-promoted self-assembly of Fmoc-protected cysteine (Fmoc-Cys), the nanovesicles Fmoc-Cys/Fe@Pc and Fmoc-Cys/Fe@Pc/ACF were prepared, which could be disassembled intracellularly. The released Fe(3+)could catalyze the transformation of H(2)O(2)enriched in cancer cells to oxygen efficiently, thereby ameliorating the hypoxic condition and promoting the photosensitizing activity of the released ZnPc. With an additional therapeutic component, Fmoc-Cys/Fe@Pc/ACF exhibited higher in vitro and in vivo photodynamic activities than Fmoc-Cys/Fe@Pc, demonstrating the synergistic effect of ZnPc and ACF.
Keywordcatalase hypoxia photodynamic therapy phthalocyanine self-assembly
DOI10.1002/anie.202010005
Language英语
WOS KeywordPHOTODYNAMIC THERAPY ; HIGHLY EFFICIENT ; NANOPARTICLES ; STRATEGY ; ACID
Funding ProjectResearch Grants Council of the Hong Kong Special Administrative Region[11300719]
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationResearch Grants Council of the Hong Kong Special Administrative Region
WOS IDWOS:000577647500001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/42384
Collection中国科学院过程工程研究所
Corresponding AuthorYan, Xuehai; Ng, Dennis K. P.; Lo, Pui-Chi
Affiliation1.City Univ Hong Kong, Dept Biomed Sci, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Li, Yongxin,Sun, Pan,Zhao, Luyang,et al. Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020:12.
APA Li, Yongxin,Sun, Pan,Zhao, Luyang,Yan, Xuehai,Ng, Dennis K. P.,&Lo, Pui-Chi.(2020).Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,12.
MLA Li, Yongxin,et al."Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020):12.
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