CAS OpenIR
Yeast-Based A beta 1-15 Vaccine Elicits Strong Immunogenicity and Attenuates Neuropathology and Cognitive Deficits in Alzheimer's Disease Transgenic Mice
Liu, Dong-qun1,2; Lu, Shuai1; Zhang, Lun1,2; Huang, Ya-ru1,2; Ji, Mei1,2; Sun, Xiao-ying1,2; Liu, Xiao-ge1,2; Liu, Rui-tian1
2020-09-01
Source PublicationVACCINES
Volume8Issue:3Pages:13
AbstractImmunotherapy focusing on reducing the amyloid-beta (A beta) burden is a promising treatment strategy for Alzheimer's disease (AD). Many clinical studies on AD immunotherapies have failed due to low safety and efficacy, calling for a highly potent AD vaccine which induces sufficient antibody titer while avoiding side effects. Here, we designed a yeast-based vaccine Y-5A15 comprising five copies of A beta 1-15 displayed on the surface of yeast cell wall, and we subcutaneously immunized APP/PS1 mice three times. Our results demonstrated that the Y-5A15 remarkably enhanced the A beta epitope immunogenicity and elicited high antibody titers against A beta in AD mice. Importantly, Y-5A15 vaccination successfully reduced A beta levels, plaque burden and glial activation, rescued synaptic deficits and significantly ameliorated memory and cognitive decline in APP/PS1 transgenic mice, suggesting that the yeast-based A beta epitope vaccine has a promising potency for the treatment of AD.
KeywordAlzheimer's disease beta-amyloid active immunotherapy yeast vaccine
DOI10.3390/vaccines8030351
Language英语
WOS KeywordAMYLOID-BETA-PROTEIN ; CROSS-PRESENTATION ; FOLLOW-UP ; IMMUNIZATION ; ANTIBODIES ; PATHOLOGY ; PEPTIDE ; PLAQUES ; AN1792 ; MODEL
Funding ProjectNational Natural Science Foundation of China[31401158] ; National Natural Science Foundation of China[81972444]
WOS Research AreaImmunology ; Research & Experimental Medicine
WOS SubjectImmunology ; Medicine, Research & Experimental
Funding OrganizationNational Natural Science Foundation of China
WOS IDWOS:000579955200001
PublisherMDPI
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/42479
Collection中国科学院过程工程研究所
Corresponding AuthorLiu, Rui-tian
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Liu, Dong-qun,Lu, Shuai,Zhang, Lun,et al. Yeast-Based A beta 1-15 Vaccine Elicits Strong Immunogenicity and Attenuates Neuropathology and Cognitive Deficits in Alzheimer's Disease Transgenic Mice[J]. VACCINES,2020,8(3):13.
APA Liu, Dong-qun.,Lu, Shuai.,Zhang, Lun.,Huang, Ya-ru.,Ji, Mei.,...&Liu, Rui-tian.(2020).Yeast-Based A beta 1-15 Vaccine Elicits Strong Immunogenicity and Attenuates Neuropathology and Cognitive Deficits in Alzheimer's Disease Transgenic Mice.VACCINES,8(3),13.
MLA Liu, Dong-qun,et al."Yeast-Based A beta 1-15 Vaccine Elicits Strong Immunogenicity and Attenuates Neuropathology and Cognitive Deficits in Alzheimer's Disease Transgenic Mice".VACCINES 8.3(2020):13.
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