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| Superparamagnetic iron oxide nanoparticles conjugated with A beta oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer's Disease | |
| Liu, Xiao-ge1,2; Zhang, Lun1,2; Lu, Shuai1; Liu, Dong-qun1; Huang, Ya-ru1,2; Zhu, Jie1; Zhou, Wei-wei1; Yu, Xiao-lin1; Liu, Rui-tian1 | |
| 2020-11-07 | |
| Source Publication | JOURNAL OF NANOBIOTECHNOLOGY
 |
| Volume | 18Issue:1Pages:13 |
| Abstract | Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder. No disease-modifying strategy to prevent or delay AD progression currently exists. A beta oligomers (A beta Os), rather than monomers or fibrils, are considered as the primary neurotoxic species. Therapeutic approaches that direct against A beta Os and promote A beta clearance may have great value for AD treatment. Results: We here reported a multifunctional superparamagnetic iron oxide nanoparticle conjugated with A beta oligomer-specific scFv antibody W20 and class A scavenger receptor activator XD4 (W20/XD4-SPIONs). Besides the diagnostic value, W20/XD4-SPIONs retained the anti-A beta properties of W20 and XD4 by inhibiting A beta aggregation, attenuating A beta O-induced cytotoxicity and increasing microglial phagocytosis of A beta. When applied to APP/PS1 mice, W20/XD4-SPIONs significantly rescued cognitive deficits and alleviated neuropathology of AD mice. Conclusion: These results suggest that W20/XD4-SPIONs show therapeutic benefits for AD. In combination with the early diagnostic property, W20/XD4-SPIONs present as a promising agent for early-stage AD diagnosis and intervention. |
| Keyword | Alzheimer's disease beta-Amyloid Oligomer Class A scavenger receptor Therapy |
| DOI | 10.1186/s12951-020-00723-1 |
| Language | 英语 |
| WOS Keyword | AMYLOID HYPOTHESIS ; MICROGLIA ; RECOGNIZE ; CELLS |
| Funding Project | National Natural Science Foundation of China[81971610] |
| WOS Research Area | Biotechnology & Applied Microbiology ; Science & Technology - Other Topics |
| WOS Subject | Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology |
| Funding Organization | National Natural Science Foundation of China |
| WOS ID | WOS:000590702000001 |
| Publisher | BMC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/42609 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Yu, Xiao-lin; Liu, Rui-tian |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Xiao-ge,Zhang, Lun,Lu, Shuai,et al. Superparamagnetic iron oxide nanoparticles conjugated with A beta oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer's Disease[J]. JOURNAL OF NANOBIOTECHNOLOGY,2020,18(1):13. |
| APA | Liu, Xiao-ge.,Zhang, Lun.,Lu, Shuai.,Liu, Dong-qun.,Huang, Ya-ru.,...&Liu, Rui-tian.(2020).Superparamagnetic iron oxide nanoparticles conjugated with A beta oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer's Disease.JOURNAL OF NANOBIOTECHNOLOGY,18(1),13. |
| MLA | Liu, Xiao-ge,et al."Superparamagnetic iron oxide nanoparticles conjugated with A beta oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer's Disease".JOURNAL OF NANOBIOTECHNOLOGY 18.1(2020):13. |
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