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| The Role of alpha-Synuclein Oligomers in Parkinson's Disease | |
Du, Xiao-yu1,2 ; Xie, Xi-xiu1; Liu, Rui-tian1
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| 2020-11-01 | |
| Source Publication | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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| Volume | 21Issue:22Pages:17 |
| Abstract | alpha-synuclein (alpha-syn) is a protein associated with the pathogenesis of Parkinson's disease (PD), the second most common neurodegeneration disease with no effective treatment. However, how alpha-syn drives the pathology of PD remains elusive. Recent studies suggest that alpha-syn oligomers are the primary cause of neurotoxicity and play a critical role in PD. In this review, we discuss the process of alpha-syn oligomers formation and the current understanding of the structures of oligomers. We also describe seed and propagation effects of oligomeric forms of alpha-syn. Then, we summarize the mechanism by which alpha-syn oligomers exert neurotoxicity and promote neurodegeneration, including mitochondrial dysfunction, endoplasmic reticulum stress, proteostasis dysregulation, synaptic impairment, cell apoptosis and neuroinflammation. Finally, we investigate treatment regimens targeting alpha-syn oligomers at present. Further research is needed to understand the structure and toxicity mechanism of different types of oligomers, so as to provide theoretical basis for the treatment of PD. |
| Keyword | α -synuclein Parkinson’ s disease oligomers structure toxicity |
| DOI | 10.3390/ijms21228645 |
| Language | 英语 |
| WOS Keyword | IN-VIVO ; NEURONAL DEGENERATION ; ACCUMULATION ; TOXICITY ; BRAIN ; DEGRADATION ; ANTIBODIES ; STRESS ; MODEL ; NEURODEGENERATION |
| Funding Project | National Natural Science Foundation of China[81971073] ; National Natural Science Foundation of China[81903531] |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry |
| WOS Subject | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| Funding Organization | National Natural Science Foundation of China |
| WOS ID | WOS:000594886400001 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/42753 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Liu, Rui-tian |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Du, Xiao-yu,Xie, Xi-xiu,Liu, Rui-tian. The Role of alpha-Synuclein Oligomers in Parkinson's Disease[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2020,21(22):17. |
| APA | Du, Xiao-yu,Xie, Xi-xiu,&Liu, Rui-tian.(2020).The Role of alpha-Synuclein Oligomers in Parkinson's Disease.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(22),17. |
| MLA | Du, Xiao-yu,et al."The Role of alpha-Synuclein Oligomers in Parkinson's Disease".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21.22(2020):17. |
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