CAS OpenIR
Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease
Liu, Linying1,2,3; Li, Yan1,2; Peng, Huan1,2; Liu, Ruiyuan1,2; Ji, Weihong1,2; Shi, Zhuyan1,2; Shen, Jie1,2; Ma, Guanghui1; Zhang, Xin1,2
2020-12-01
Source PublicationSCIENCE ADVANCES
ISSN2375-2548
Volume6Issue:50Pages:11
AbstractThe most critical problem in the treatment of neurodegenerative diseases is brain neuronal protection, which can be overcome by clearing pathological substances and regulating the immune environment. In the above treatment strategies, the traditional poor drug delivery problem is inevitable. Here, we show an engineering core-shell hybrid system named rabies virus glycoprotein (RVG) peptide-modified exosome (EXO) curcumin/phenylboronic acid-poly(2-(dimethylamino)ethyl acrylate) nanoparticle/small interfering RNA targeting SNCA (REXO-C/ANP/S). It is a nanoscavenger for clearing alpha-synuclein aggregates and reducing their cytotoxicity in Parkinson's disease neurons. The motor behavior of Parkinson's disease mice is substantially improved after REXO-C/ANP/S treatment. In particular, we demonstrate that REXO-C/ANP/S is also a nanoscavenger for clearing immune activation due to its natural immature dendritic cell EXO coating. Our findings show that REXO-C/ANP/S may serve as a platform for neurodegenerative diseases treatment.
DOI10.1126/sciadv.aba3967
Language英语
WOS KeywordDENDRITIC CELLS ; SIRNA DELIVERY ; MOTOR DYSFUNCTION ; CURCUMIN ; BRAIN ; AGGREGATION ; INDUCTION ; IL-10
Funding ProjectBeijing Nova Program[Z201100006820140] ; National High Technology Research and Development Program[2016YFA0200303] ; National Natural Science Foundation of China[21905283] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; Beijing Natural Science Foundation[2192057] ; Beijing Natural Science Foundation[L172046]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
Funding OrganizationBeijing Nova Program ; National High Technology Research and Development Program ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS IDWOS:000599903600002
PublisherAMER ASSOC ADVANCEMENT SCIENCE
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/42841
Collection中国科学院过程工程研究所
Corresponding AuthorZhang, Xin
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Beijing Polytech, Coll Bioengn, Beijing 100176, Peoples R China
Recommended Citation
GB/T 7714
Liu, Linying,Li, Yan,Peng, Huan,et al. Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease[J]. SCIENCE ADVANCES,2020,6(50):11.
APA Liu, Linying.,Li, Yan.,Peng, Huan.,Liu, Ruiyuan.,Ji, Weihong.,...&Zhang, Xin.(2020).Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease.SCIENCE ADVANCES,6(50),11.
MLA Liu, Linying,et al."Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease".SCIENCE ADVANCES 6.50(2020):11.
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