Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease

doi:10.1126/sciadv.aba3967

CAS OpenIR

	Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease
	Liu, Linying 1,2,3; Li, Yan 1,2; Peng, Huan 1,2; Liu, Ruiyuan 1,2; Ji, Weihong 1,2; Shi, Zhuyan 1,2; Shen, Jie 1,2; Ma, Guanghui 1; Zhang, Xin 1,2
	2020-12-01
Source Publication	SCIENCE ADVANCES
ISSN	2375-2548
Volume	6 Issue:50 Pages:11
Abstract	The most critical problem in the treatment of neurodegenerative diseases is brain neuronal protection, which can be overcome by clearing pathological substances and regulating the immune environment. In the above treatment strategies, the traditional poor drug delivery problem is inevitable. Here, we show an engineering core-shell hybrid system named rabies virus glycoprotein (RVG) peptide-modified exosome (EXO) curcumin/phenylboronic acid-poly(2-(dimethylamino)ethyl acrylate) nanoparticle/small interfering RNA targeting SNCA (REXO-C/ANP/S). It is a nanoscavenger for clearing alpha-synuclein aggregates and reducing their cytotoxicity in Parkinson's disease neurons. The motor behavior of Parkinson's disease mice is substantially improved after REXO-C/ANP/S treatment. In particular, we demonstrate that REXO-C/ANP/S is also a nanoscavenger for clearing immune activation due to its natural immature dendritic cell EXO coating. Our findings show that REXO-C/ANP/S may serve as a platform for neurodegenerative diseases treatment.
DOI	10.1126/sciadv.aba3967
Language	英语
WOS Keyword	DENDRITIC CELLS ; SIRNA DELIVERY ; MOTOR DYSFUNCTION ; CURCUMIN ; BRAIN ; AGGREGATION ; INDUCTION ; IL-10
Funding Project	Beijing Nova Program[Z201100006820140] ; National High Technology Research and Development Program[2016YFA0200303] ; National Natural Science Foundation of China[21905283] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; Beijing Natural Science Foundation[2192057] ; Beijing Natural Science Foundation[L172046]
WOS Research Area	Science & Technology - Other Topics
WOS Subject	Multidisciplinary Sciences
Funding Organization	Beijing Nova Program ; National High Technology Research and Development Program ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS ID	WOS:000599903600002
Publisher	AMER ASSOC ADVANCEMENT SCIENCE
Citation statistics
Document Type	期刊论文
Identifier	http://ir.ipe.ac.cn/handle/122111/42841
Collection	中国科学院过程工程研究所
Corresponding Author	Zhang, Xin
Affiliation	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Beijing Polytech, Coll Bioengn, Beijing 100176, Peoples R China
Recommended Citation GB/T 7714	Liu, Linying,Li, Yan,Peng, Huan,et al. Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease[J]. SCIENCE ADVANCES,2020,6(50):11.
APA	Liu, Linying.,Li, Yan.,Peng, Huan.,Liu, Ruiyuan.,Ji, Weihong.,...&Zhang, Xin.(2020).Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease.SCIENCE ADVANCES,6(50),11.
MLA	Liu, Linying,et al."Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease".SCIENCE ADVANCES 6.50(2020):11.

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh

中国科学院过程工程研究所机构知识库