CAS OpenIR
pH-sensitive zwitterionic polycarboxybetaine as a potential non-viral vector for small interfering RNA delivery
Peng, Huan1,2; Ji, Weihong1,2; Zhao, Ruichen1,2; Lu, Zhiguo1,2; Yang, Jun1; Li, Yan1; Zhang, Xin1
2020-12-20
Source PublicationRSC ADVANCES
Volume10Issue:73Pages:45059-45066
AbstractSmall interfering RNA (siRNA) has great potential for the treatment of various diseases. However, its intrinsic deficiencies seriously limit its application. Herein, pH-sensitive zwitterionic polymer polycarboxybetaine (PCB) was developed as a non-viral vector for siRNA. The PCB could be protonated in an acidic environment and become positively charged from a cancer site. After protonation, PCB could complex siRNA via electrostatic interaction, and its loading ability was enhanced with a decrease of pH value. Compared with the PEI 10k, PCB50 with a similar molecular weight had comparable siRNA loading ability and lower cytotoxicity. Besides, siRNA loaded by PCB50 could escape from endosomes and reduce the loss of drugs, and based on the excellent uptake and obvious apoptotic effect on HeLa cells, the pH-sensitive PCB with low cytotoxicity could be used as a non-viral vector for safe siRNA delivery for cancer treatment.
DOI10.1039/d0ra09359a
Language英语
WOS KeywordIN-VIVO ; SIRNA ; GENE ; POLYETHYLENIMINE ; THERAPEUTICS ; POLYMER ; LIPOSOMES ; SERUM
Funding ProjectBeijing Natural Science Foundation[L172046] ; Beijing Natural Science Foundation[2192057] ; Beijing Nova Program[Z201100006820140] ; National High Technology Research and Development Program[2016YFA0200303] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[21905283]
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationBeijing Natural Science Foundation ; Beijing Nova Program ; National High Technology Research and Development Program ; National Natural Science Foundation of China
WOS IDWOS:000601124900049
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/42908
Collection中国科学院过程工程研究所
Corresponding AuthorLi, Yan; Zhang, Xin
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Peng, Huan,Ji, Weihong,Zhao, Ruichen,et al. pH-sensitive zwitterionic polycarboxybetaine as a potential non-viral vector for small interfering RNA delivery[J]. RSC ADVANCES,2020,10(73):45059-45066.
APA Peng, Huan.,Ji, Weihong.,Zhao, Ruichen.,Lu, Zhiguo.,Yang, Jun.,...&Zhang, Xin.(2020).pH-sensitive zwitterionic polycarboxybetaine as a potential non-viral vector for small interfering RNA delivery.RSC ADVANCES,10(73),45059-45066.
MLA Peng, Huan,et al."pH-sensitive zwitterionic polycarboxybetaine as a potential non-viral vector for small interfering RNA delivery".RSC ADVANCES 10.73(2020):45059-45066.
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